免疫细胞治疗联合化疗治疗晚期卵巢癌患者的疗效及对细胞免疫的影响

Effect of immunocytotherapy combined with chemotherapy on advanced ovarian cancer and its effect on cellular immunity

目的:观察免疫细胞治疗联合化疗治疗晚期卵巢癌患者的疗效及对细胞免疫的影响。方法:2014年1月至2016年12月在普陀区人民医院收治的Ⅳ期卵巢癌患者102例,按照随机数字法将患者分为观察组和对照组,每组各51例,对照组予以传统化疗,观察组在对照组的基础上予以免疫细胞治疗。观察两组的疗效、治疗前后总生命质量评分(TQLS)、抑郁自评量表评分(SDS)、焦虑自评量表(SAS)、白介素(IL)-6、IL-10、干扰素(INF)-γ、IL-2、CD3^+、CD4^+、CD8^+和CD4^+/CD8^+水平的变化。结果:观察组的总有效率为66.67%明显高于对照组的43.14%,两组比较差异有统计学意义(P<0.05)。两组治疗前TQLS、SDS和SAS评分差异无统计学意义(P>0.05),治疗后TQLS、SDS和SAS评分较治疗前明显降低(P<0.01),而观察组降低的更明显(P<0.01)。术前IL-6、IL-10、INF-γ、IL-2、CD3^+、CD4^+、CD8^+和CD4^+/CD8^+水平差异无统计学意义(P>0.05),治疗后观察组的IL-6、IL-10和CD8^+水平较治疗前明显降低(P<0.01),对照组较治疗前明显升高(P<0.01),观察组较对照组明显降低(P<0.01);观察组的INF-γ、IL-2、CD3^+、CD4^+和CD4^+/CD8^+水平较治疗前明显升高(P<0.01),对照组较治疗前明显降低(P<0.01),而观察组较对照组明显升高(P<0.01)。结论:免疫细胞治疗联合化疗对晚期卵巢癌患者的疗效显著,具有提高生活质量,缓解患者的焦虑和抑郁,与机体的细胞免疫提高有关。

Objective：To observe the effect of immunocytotherapy combined with chemotherapy on advanced ovarian cancer and its effect on cellular immunity.Methods：102 patients with stage Ⅳ ovarian cancer,from January 2014 to December 2016,were divided into observation group and control group according to the random number method,each group had 51 cases.Control group were treated with traditional chemotherapy and observation group were performed with the immune cell therapy on the basis of control group.The levels of total quality of life score （TQLS）,self-rating depression scale （SDS）,self-rating anxiety scale （SAS）,interleukin （IL）-6,IL-10,interferon （INF）-γ,IL-2,CD3＋,CD4＋,CD8＋ and CD4＋/CD8＋ were observed before and after treatment.Results：The total effective rate was 66.67% in observation group,which was higher than 43.14% in control group （P〈0.05）.The levels of TQLS,SDS and SAS were no significant difference between the two groups （P〉0.05）.After treatment,the levels of TQLS,SDS and SAS were significantly lower than those before treatment （P〈0.01）.There was no significant difference in IL-6,IL-10,INF-γ,IL-2,CD3＋,CD4＋,CD8＋ and CD4＋/CD8＋ levels between the two groups （P〉0.05）.After treatment,the levels of IL-6,IL-10 and CD8＋ in observation group were significantly lower than those in control group （P〈0.01）,and the levels of those in control group were significantly higher compared with the control group （P〈0.01）,the levels of INF-γ,IL-2,CD3＋,CD4＋ and CD4＋/ CD8＋ in observation group were significantly higher than those before treatment （P〈0.01）,the levels of those in control group were significantly lower than those before treatment （P〈0.01）,and the levels of those in observation group were significantly higher than those in control group （P〈0.01）.Conclusion：The effect of immunocytotherapy combined with chemotherapy on advanced ovarian cancer is obvious,which can improve the quality of life,relieve anxiety and depression,which is related to the improvement of cellular immunity.