Ommaya囊在中枢系统白血病治疗中应用1例报道并文献复习

Case report of the application Ommaya reservoir in the treatment of central nervous system leukemia and the literature review

目的:探讨中枢神经系统白血病(CNSL)的临床病理特征、治疗方式的选择和预后认识,探讨Ommaya囊在白血病中枢系统侵犯中应用的可行性。方法:分析2012年1月齐齐哈尔市第一医院初诊收治的1例诊断为急性早幼粒细胞白血病,经脑脊液等检查确诊为中枢神经系统白血病(CNSL)的患者,经Ommaya囊治疗后状态及文献复习。结果:患者在完全缓解期并发神经系统(CNS)损害,经置入Ommaya囊,反复穿刺注射三联化疗药物,CNS症状获得明显改善。结论:急性白血病易并发中枢神经系统侵润;CNSL损害临床表现各有不同;Ommaya囊在腰椎穿刺困难的CNSL治疗中存在可行性。

Objective：To investigate the clinical and pathological characteristics,treatment modality and prognosis of central nervous system leukemia （CNSL）,and to explore the feasibility of the application of Ommaya capsule in the treatment of central nervous system.Methods：1 patient was admitted to the First Hospital of Qiqihar in January 2012 newly diagnosed as acute promyelocytic leukemia,with the cerebrospinal fluid examination confirmed central nervous system leukemia （CNSL） patients.Ommaya capsule after treatment status and review of the literature were analysed.Results：The patients in complete remission （CNS） was complicated with nervous system damage.After the placement of Ommaya capsule,repeated puncture and injection of three combined chemotherapy drugs,CNS symptoms significantly improved.Conclusion：Acute leukemia is complicated with central nervous system invasion easily.Clinical manifestations of the CNSL damage are different.Ommaya capsule shows feasibility in CNSL treatment of difficult lumbar puncture.