PRDM14在肿瘤中的研究进展

Progress of PRDM14 in tumor research

正性调节区锌指蛋白14(PR domain zinc finger protein 14,PRDM14)具有1个PR结构域和6个锌指结构,是PRDM家族具有代表性的成员之一。PRDM家族与人类肿瘤形成相关,在细胞分化和恶变过程中发挥着重要作用。PRDM家族各个成员都有一个PR-domain区域,该区域与SET-domain具有高度同源性。国内外研究发现,在多种肿瘤发生发展过程中,PRDM家族成员均有异常表达现象。近年来关于PRDM14与肿瘤的研究逐渐增多,显示其在不同肿瘤类型中发挥不同作用,有研究表明PRDM14还可以作为恶性肿瘤的一个很好的药物靶标。本文介绍PRDM14的结构及功能,并重点阐述PRDM14在肿瘤发生发展中的意义及相关研究进展。

PR domain 14 （PRDM14） has a PR domain and six zinc finger structures,and is one of the representative members of the PRDM family.PRDM family is associated with human tumor formation and plays an important role in cell differentiation and malignant transformation.Each member of PRDM family has a PR-domain region,which has high homology with SET-domain.At home and abroad,it has been found that PRDM family members are abnormally expressed during the development of various tumors.In recent years,studies on PRDM14 and tumor gradually have increased,showing its different roles in different tumor types,studies have shown that PRDM14 can also serve as a good drug target malignant tumors.In this paper,the structure and function of PRDM gene were introduced,and the significance of PRDM14 in tumorigenesis and its related research progress was expounded.