重症手足口病早期识别实验室检查的研究进展

Research progress on early identification of severe hand,foot and mouth disease from laboratory examination

手足口病(HFMD)是多种肠道病毒感染引起的一种急性传染病,好发于3岁以下儿童。大部分患儿可自愈,但少部分患儿,尤其是EV71型感染的患儿可迅速进展为重症。并发神经系统损害和心肺功能损害,遗留严重后遗症,极少数患儿甚至死亡,给患儿家庭和社会带来严重负担。本文献复习对重症重型和重症危重型手足口病的临床表现、发病机制,特别是实验室检查中能提示病情进展的指标进行综述。早期识别和诊断重症手足口病,为临床救治重症手足口病提供可靠的科学理论依据。

Hand foot and mouth disease （HFMD）is an acute infectious disease caused by enterovirus infection,mostly affecting children under 3 years old.HFMD in most patients can be self-healing,but in few children,especially in children with type EV71 infection can rapidly progress to severe HFMD.Because of the damage to nervous system and cardiopulmonary function,HFMD may lead to serious sequelae,in patients and even death in few children,putting heavy burden for families and society.This literature review focuses on clinical manifestations and pathogenesis of the severe severe and critical severe HFMD,especially the laboratory examination marker which can predict disease progress.Early identification and diagnosis of severe HFMD can provide reliable scientific basis for clinical treatment.