儿童血清维生素A、D、E水平与肺炎支原体肺炎相关性的临床研究

Clinical study on the correlation between serum vitamin A,D,E levels with mycoplasma pneumoniae pneumonia in children

目的研究儿童血清维生素A、D、E水平与肺炎支原体肺炎的相关性,为临床防治提供指导。方法选取肺炎支原体肺炎住院治疗患儿415例为支原体肺炎组,儿保科非呼吸道感染儿童431例为对照组。分别检测两组儿童血清维生素A、D、E水平。结果支原体肺炎组血清维生素A、D、E平均值均明显低于对照组(P<0.01);维生素A缺乏例数明显高于对照组(P<0.01),亚临床维生素A缺乏例数与对照组相比差异无统计学意义(P>0.05);维生素D缺乏及不足例数均明显高于对照组(P<0.01);维生素E缺乏例数明显高于对照组(P<0.01)。结论维生素A、D、E缺乏与肺炎支原体肺炎的发病相关,特别是缺乏维生素A,补充维生素A、D、E有可能对预防肺炎支原体肺炎反复发作有益,其具体机制有待于进一步探讨。

Objective To investigate the correlation between serum vitamin A,D,E levels and mycoplasma pneumoniae pneumonia,and to provide guidance for clinical prevention and treatment. Methods A total of 415 cases of children hospitalized with mycoplasma pneumonia were selected as mycoplasma pneumonia group,and 431 children from child healthcare department without respiratory tract infection were selected as control group.The serum vitamin A,D,E in two groups were detected. Results The average levels of serum vitamin A,D and E in mycoplasma pneumonia group were significantly lower than those in control group （P〈0.01）;The cases of vitamin A deficiency in mycoplasma pneumonia group were more than that in control group （P〈0.01）.There was no significant difference on the cases of subclinical vitamin A deficiency between two groups （P〉0.05）;The cases lack of vitamin D and vitamin D deficiency in mycoplasma pneumonia group were significantly more than those in the control group （P〈0.01）;The cases of vitamin E deficiency was more than that in control group significantly （P〈0.01）. Conclusion Vitamin A,D,E deficiency,especially lack of vitamin D,are associated with the mycoplasma pneumonia.Supplementation of vitamin A,D,E may prevent recurrent pneumonia mycoplasma pneumonia,and the specific mechanism still needs to be further explored.