中药银屑病一号方治疗血热型银屑病的疗效观察

Clinical Observation of Chinese Medicinal Recipe Psoriasis No.1 Formula in Treating Blood-heat Type of Psoriasis

【目的】观察中药银屑病一号方治疗血热型银屑病的临床疗效和安全性。【方法】将80例血热型银屑病患者随机分为试验组和对照组,每组各40例。试验组患者给予口服中药银屑病一号方(由生地黄、白茅根、牡丹皮、土茯苓、甘草、槐花、紫草、赤芍、大青叶、蝉衣、黄芩、当归等组成)治疗,对照组患者给予口服复方青黛胶囊治疗,2组疗程均为8周。观察2组患者治疗前后银屑病面积与严重性指数(PASI)评分和白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)含量的变化情况,并评价2组的临床疗效及不良反应情况。【结果】(1)治疗后,2组患者的PASI评分均较治疗前显著降低(P<0.01),且试验组对PASI评分的降低作用明显优于对照组(P<0.05)。(2)试验组的总有效率为87.5%,高于对照组的67.5%,但组间比较,差异无统计学意义(P>0.05)。(3)治疗后,2组患者IL-17和TNF-α含量均较治疗前明显降低(P<0.01),但治疗后组间比较,差异均无统计学意义(P>0.05)。(4)治疗过程中,2组患者均未出现严重不良反应。【结论】中药银屑病一号方治疗血热型银屑病疗效显著,并且具有较高的安全性,其疗效优于复方青黛胶囊。

Objective To observe the clinical efficacy and safety of Chinese medicinal recipe Psoriasis No.1 Formula in treating blood-heat type of psoriasis. Methods Eighty patients with blood-heat syndrome wererandomly divided into trial group and control group,40 cases in each group. The trial group was given oral use of the decoction of Psoriasis No. 1 Formula（mainly composed of Radix Rehmanniae, Rhizoma Imperatae,Cortex Moutan,Rhizoma Smilacis Glabrae,Radix Glycyrrhizae,Flos Sophorae,Radix Arnebiae seu Lithospermi,Radix Paeoniae Rubra, Folium Isatidis, Periostracum Cicadae, Radix Scutellariae, and Radix Angelicae Sinensis）. The control group was given Compound Qingdai Capsules orally. The treatment for the two groups covered 8 weeks. Psoriasis Area Severity Index（PASI）scores,and contents of interleukin-17（IL-17）and tumor necrosis alpha（TNF-α） were observed before and after treatment. And clinical efficacy and adverse reactions were compared between the two groups after treatment. Results（1） PASI scores of the two groups were significantly lowered after treatmen（tP 0.01 compared with those before treatmen）t,and the trial group had stronger effect on decreasing PASI scores than the control group（P 0.05）.（2）The total effective rate of the trial group was 87.5%, higher than the control group（67.5%）, but the difference was insignificant（P 0.05）.（3）After treatment,contents of IL-17 and TNF-α of the two groups were markedly decreased（P 0.01 compared with those before treatmen）t,but the difference was insignificant between the two groups（P 0.05）.（4）No severe adverse effect was found in the two groups during the treatment. Conclusion Chinese medicinal recipe Psoriasis No.1 Formula is effective and safe in treating blood-heat type of psoriasis, and its effect is superior to that of Compound Qingdai Capsules.