心理评估对乳腺癌患者诊治的临床价值及化疗前后血清IL-1β、TNF-ɑ水平变化和临床意义

Clinical Significance of Psychological Assessment in the Diagnosis and Treatment of Breast Cancer Patients and the Changes of Derum IL-1β and TNF-ɑ Levels Before and After Chemotherapy and iIts Clinical Significance

目的探究心理评估对乳腺癌患者诊治的临床价值及化疗前后血清中IL-1β、TNF-ɑ水平变化和临床意义。方法通过观察临床中收集的乳腺癌患者140例,将其分为单纯化疗药物治疗对照组70例(A组);心理评估组70例(B组);两组患者均进行常规化疗药物治疗,B组患者在治疗过程中进行心理水平评估,并据此对治疗方案进行调整并给予适当的心理干预治疗,并检测两组患者血清中IL-1β、TNF-ɑ水平并比较检测值结果的变化差异来探讨其临床意义与治疗效果的关系。结果两组患者经治疗后IL-1β、TNF-ɑ的含量较治疗前均明显降低(P<0.05),B组较A组降低明显(P<0.05);A、B两组患者治疗后心理抑郁状态都有所改善,B组较A组心理评分更低。结论 (1)在临床治疗过程中,心理评估联合化疗治疗乳腺癌疗效优于单纯化疗患者。应将对乳腺癌患者进行心理评估运用到临床治疗中去,及时进行治疗方案的调整会明显改善患者的生活质量及临床症状,提高临床疗效;(2)在诊治过程中,对患者进行心理方面评估将更好的指导临床治疗,对患者的预后有更清晰的认识,更有益于改善患者的远期预后及生活质量,也为临床工作者提供了新的治疗方法;(3)临床工作中可以通过IL-1β、TNF-ɑ的异常变化来预测乳腺癌患者的治疗效果、疾病的严重程度及预后。

Abstract OBJECTIVE To explore the clinical value of psychological assessment in the diagnosis and treatment of breast cancer pa- tients and the changes of serum IL-1β and TNF-α levels before and after chemotherapy and its clinical significance. METHODS A to- tal of 140 patients with breast cancer collected were divided into chemotherapy group （n=70） and control group （n=70） （group B）. Both groups were treated with conventional chemotherapy, Group B patients in the course of treatment to assess the psychological lev- el, and accordingly adjust the treatment program and give appropriate psychological intervention, and test the serum levels of IL-1β , TNF-α in both groups and compare the results of the test Changes in the relationship between the clinical significance and the effect of treatment. RESULTS After treatment, the levels of IL-1β and TNF-α in the two groups were significantly lower than those before treatment （P〈0.05）, and the difference between group B and group A （P〈0.05）. Psychological depression had improved, B group than the A group of psychological score lower. CONCLUSION （1） In the course of clinical treatment, psychological evaluation com- bined with chemotherapy in the treatment of breast cancer was better than chemotherapy alone. It should be on the psychological eval- uation of breast cancer patients to the clinical treatment to the timely treatment of the program will significantly improve the quality of life and clinical symptoms, improve clinical efficacy; （2） in the diagnosis and treatment process, the psychological aspects of patients Assessment will better guide the clinical treatment, the prognosis of patients with a clearer understanding, more conducive to improv- ing the patient＇s long-term prognosis and quality of life, but also for clinical workers to provide a new treatment; （3） clinical work could be through the abnormal changes in IL-1β ,TNF-α to predict the treatment of breast cancer patients, the severity of the disease and prognosis.