BK通道的生物物理特性与门控及其最新研究进展

The Research Progresses of Biophysical Properties and Gating Mechanisms of BK Channel

BK_(Ca)通道是细胞膜上受Ca^(2+)和膜电位双重调控的离子通道,其与细胞信号系统偶联并发挥着重要作用,该通道高度表达于高等动物的多种组织.最近的研究证实,在心肌细胞膜上存在力敏感BK通道并参与了心脏收缩与舒张的调控.本文将介绍BK通道与L-型钙通道功能上的耦合,心肌细胞质膜力敏感BK通道门控和功能的研究,以及对基底刚度的响应.这有助于更好地理解力敏感离子通道相关心脏疾病的病理和生理学基础.

Large conductance Ca〉 activated potassium channels are regulated by both intracellular Ca2~ and membrane potential. BK channel couples membrane voltage with the intracellular signal system, that plays important roles for cellular functions. BK channel is widely and densely expressed in various tissues of many species. Recent studies have demonstrated that BK channel was expressed in cardiomyocytes and involved in the regulation of cardiac systolic and diastolic. In this work, we present some progress in the study of coupling between BK channel and L-type Ca2＋ channel gating and the function of cardiomyocyte BK channels as well as the response to substrate stiffness. These reports will help to understand the pathophysiology of mechano-sensitive ion channel-associated heart diseases.