血尿酸与老年慢性肾脏病非透析患者颈动脉斑块总积分的相关性分析

Relationship between blood uric acid and total carotid plaque burden in elderly patients with non-dialysis dependent chronic kidney disease

目的探讨老年慢性肾脏病（CKD）非透析患者尿酸与颈动脉斑块积分的相关性。方法前瞻性连续选取慢性老年CKD非透析住院患者77例，采集相关临床资料和实验室检查资料，完成颈动脉超声检查，计算颈动脉斑块总积分，多元线性回归分析颈动脉斑块积分独立相关因素。结果（1）吸烟、高血压、糖尿病组较对照组颈动脉斑块总积分高（P=0．035、0．014、0．041）。（2）颈动脉斑块总积分与血红蛋白、低密度脂蛋白胆固醇、尿酸、c反应蛋白、肌酐、估算。肾小球滤过率存在单变量相关。（3）尿酸、低密度脂蛋白胆固醇与颈动脉斑块总积分独立相关（P=0．007、0．001）。结论尿酸是老年CKD非透析患者颈动脉粥样硬化的独立危险因素。

Objective To investigate the relationship between blood uric acid levels and total burden scores（TBS）of carotid plaques in elderly patients with non-dialysis dependent chronic kidney disease（CKD）. Methods Seventy-seven elderly patients with non-dialysis dependent CKD were included. All clinical data were collected, and stepwise multiple linear regression was conducted to determine independent factors for TBS of carotid plaques in elderly patients with non-dialysis dependent CKD. Results Compared with the control group, TBS was significantly higher in the smoking group（P= 0.035）,hypertension group（P= 0.014） and diabetic group（P= 0.041）.In addition, correlation analysis showed that hemoglobin, low-density lipoprotein cholesterol, uric acid, C- react protein and estimated glomerular filtration rate were significantly correlated with TBS（all P〈 0.05）. Furthermore, stepwise multiple linear regression analysis showed that TBS was markedly correlated with low-density lipoprotein cholesterol （P = 0. 007,） and uric acid （P = 0. 001 ） . Conclusions Uric acid is an independent factor for TBS of carotid plaques in elderly patients with non- dialysis dependent CKD.