乳腺癌骨转移患者血液OSC、OPG、NTX及与尿液NTX水平相关性探讨

To study the relationship between urine NTX and serum OSC,OPG and NTX in patients with bone metastasis of breast cancer

目的:探讨乳腺癌骨转移患者血液骨钙素(OSC)、骨保护素(OPG)、Ⅰ型胶原吡啶交联氨基末端肽(NTX)及与尿液NTX水平的相关性。方法:通过对比40例乳腺癌骨转移患者(实验组)和40例健康女性(对照组)血液OSC、OPG、NTX和尿液NTX水平,比较实验组治疗前和对照组的血液OSC、OPG、NTX和尿液NTX水平的差异。评估血液OSC与血液NTX水平相关性,血液OPG与血液NTX水平相关性,血液和尿液NTX水平相关性。结果:实验组中血液OSC、OPG和NTX水平比对照组要高,两组的OSC差异具有统计学意义(P<0.001),两组的OPG差异具有统计学意义(P<0.003),两组的NTX差异具有统计学意义(P<0.001)。相关性统计结果显示血液中的NTX的升高和血液中的OSC及OPG水平具有关性,血液NTX和OSC之间的r=0.768(P<0.001),血液NTX和OPG之间的r=0.685(P<0.001),差异均具有统计学意义;血液NTX和尿液NTX之间也具有相关性r=0.638(P<0.005),差异具有统计学意义。结论:乳腺癌骨转移的患者血液OSC、OPG、NTX及与尿液NTX水平之间具有一定关系,且有一定的临床意义。

Objective：To investigate the relationship between the serum osteocalcin（OSC）,osteoprotegerin（OPG）,serum and urine type I collagen pyridinoline cross-linked N-telopeptides（NTX） in patients with bone metastasis of breast cancer.Methods：40 cases of breast cancer patients with bone metastasis was experimental group and 40 healthy women was control group,the serum OSC,OPG,NTX,and NTX in urine between the experimental group before treatment and control group was compared.The correlation of serum OSC and serum NTX,serum OPG and serum NTX,serum and urine NTX was evaluated.Results：The serum OSC,OPG and NTX in the experimental group were higher than the control group.The OSC level was statistically significant difference between the two groups（P〈0.001）.The OPG level was statistically significant difference between the two groups（P〈0.003）.The NTX level was statistically significant difference between the two groups（P〈0.001）.The correlation results showed that the serum level of NTX increased had intimate correlation to the serum OSC and OPG level,the correlation coefficient between serum NXT and OSC was 0.768（P〈0.001）,the correlation coefficient between serum NXT and OPG was 0.685（P〈0.001）,the correlation coefficient between serum and urine NTX was 0.638（P〈0.005）,with statistical significance.Conclusion：The serum OSC,OPG,NTX and urine NTX in the breast cancer patients with bone metastasis has a certain correlation,has certain clinical significance.