腹腔镜卵巢移位对年轻中晚期宫颈鳞癌患者同步放化疗后卵巢功能的影响

Effect of laparoscopic ovarian transposition in young patients with medium-term and advanced cervical squamous cell carcinoma after concurrent chemoradiotherapy

目的:研究腹腔镜卵巢移位对年轻中晚期宫颈癌同步放化疗后卵巢功能的影响。方法:对我院2012至2016年年轻中晚期宫颈癌进行同步放化疗的患者进行对照研究,将患者分为手术组和对照组,比较两组患者身高、体重、体重指数、术前血清促卵泡成熟激素(FSH)、黄体生成激素(LH)和雌二醇(E2)水平。首次放化疗后3、6、12个月检查患者血清中FSH、LH、E2以及Kupperman评分,比较两组患者的差异。结果:经筛选后共47例患者纳入研究,其中手术组20例,对照组27例。两组患者术前各项参数均无差异(P>0.05)。治疗后3个月两组患者各项指标均无差异(P>0.05)。治疗后6个月和12个月手术组患者血清FSH低于对照组(P<0.05),E2高于对照组(P<0.05),Kupperman评分低于对照组(P<0.05)。治疗后12个月手术组患者血清LH水平低于对照组(P<0.05)。结论:腹腔镜卵巢移位术对年轻中晚期宫颈癌同步放化疗后卵巢功能的保护具有积极作用。

Objective：To study the effect of laparoscopic ovarian transposition in young patients with medium-term and advanced cervical squamous cell carcinoma after concurrent chemoradiotherapy.Methods：Patients with medium-term and advanced cervical squamous cell carcinoma from our hospital during 2012 to 2016 were included in this study.Patients were separated into surgery group and control group.Data such as age,weight,BMI and the serum level of follicle-stimulating hormone （FSH）,luteinizing hormone （LH） and estradiol （E2） were collected before treatment.After 3,6 and 12 months,serum level of follicle- stimulating hormone （FSH）,luteinizing hormone （LH） and estradiol （E2） were detected.And Kupperman index were measured in the same time.Results：47 patients were identified during the study period and ovarian transposition was performed via laparoscopy in 20 patients before concurrent chemoradiotherapy.There was no significant difference in patient characteristics and serum level of pretherapy FSH,LH and E2 between 2 groups（P〉0.05）.There was no significant difference ovarian function and Kupperman index between 2 groups in the third month after the first chemoradiotherapy（P〉0.05）.Serum level of FSH and Kupperman index were markedly lower in surgery group than that of control group and Serum level of E2 index were significantly higher in operation group than that of control group after 6 and 12 month（P〈0.05）.Serum level of LH was significantly lower in surgery group than that of control group after 12 month（P〈0.05）.Conclusion：Laparoscopic ovarian transposition is an effective way for preserving ovarian function in young patients with medium-term and advanced cervical squamous cell carcinoma after concurrent chemoradiotherapy.