不可逆电穿孔消融在治疗恶性肿瘤中的应用进展

The progress of irreversible electroporation ablation in cancer treatment

不可逆电穿孔是一种全新的肿瘤消融技术,该技术利用脉冲电场在细胞膜上造成不可逆的纳米级孔洞,从而使肿瘤细胞死亡,这是一种独特的非热效应灭活机制。近年来,越多来越多的临床试验证实了不可逆电穿孔消融技术在恶性肿瘤治疗中的安全性及有效性。本文就目前不可逆电穿孔消融应用于恶性肿瘤治疗的临床研究进展作一综述。

Irreversible electroporation ablation is a brand-new cancer ablation technology.This technology can use electric pulse leading to nano holes in cell membrane and inducing cell death,which is a distinct nonthermal ablation.Recently,a large number of clinical tests demonstrated the safety and availability of irreversible electroporation ablation in treatment of cancer.This article aims to make a brief review about its progress in clinical research.