摘要
研究臭牡丹Clerodendrum bungei的化学成分。采用硅胶,Sephadex LH-20,MCI,ODS和半制备HPLC等色谱技术,从臭牡丹95%乙醇提取物中分离得到10个化合物,分别鉴定为11,12,16S-trihydroxy-7-oxo-17(15→16),18(4→3)-diabeo-abieta-3,8,11,13-tetraen-18-oic acid(1),12 S*,13R*-dihydroxy-9-oxo-octadeca-10(E)-enoic acid(2),赪桐苷A(3),trichotomoside(4),山橘脂酸(5),4'-O-methylscutellarein(6),neroplomacrol(7),butylitaconic acid(8),hexylitaconic acid(9),对羟基苯甲酸(10)。化合物1和2为新天然产物,化合物7~10为首次从该属植物中分离得到,化合物为3,5,6首次从该植物中分离得到。
Ten compounds were isolated from the 95% aqueous EtOH extract of Clerodendrum bungei by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, ODS, and semi-preparative HPLC. Their structures were elucidated as 11,12,16S-trihydroxy-7-oxo-17(15→16),18(4→3)-diabeo-abieta-3,8,11,13-tetraen-18-oic acid (1), 12S*,13R*-dihydroxy-9-oxo-octadeca-10(E)-enoic acid (2), clerodenoside A (3), trichotomoside (4), glycosmisic acid (5), 4'-O-methylscutellarein (6), neroplomacrol (7), butylitaconic acid (8), hexylitaconic acid (9), p-hydroxybenzonic acid (10) by their physicochemical properties and spectroscopic data. Compounds 1 and 2 are new natural products, while compounds 7-10 were obtained from the genus Clerodendrum for the first time, and compounds 3, 5, 6 were isolated from this plant for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第24期4788-4793,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(21562017)
广西自然科学基金项目(2014GXNSFBA118189)
关键词
臭牡丹
马鞭草科
化学成分
二萜
Clerodendrum bungei
Verbenaceae
chemical constituents
diterpenoids