大气细颗粒物可通过长链非编码RNA途径促进肺癌细胞的迁移侵袭

PM_(2.5) exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells

长期暴露于大气细颗粒物（PM2.5）可能造成或加剧包括肺癌在内的多种疾病,但机制尚未完全清楚。新发现的长链非编码RNA虽然不能编码蛋白质,却能调控多种生命活动并参与肿瘤的发生发展。研究者将肺腺癌A549细胞暴露于PM2.5混悬的DMEM细胞培养基,构建肺癌细胞暴露PM2.5模型;实时荧光定量PCR检测长链非编码RNA loc146880的表达水平;