干细胞治疗下肢缺血性疾病的Meta分析

Meta analysis of stem cells in the treatment of lower extremity ischemic disease

目的:采用Meta分析综合评价干细胞治疗下肢缺血性疾病的疗效。方法 :利用计算机检索国内外发表的有关干细胞治疗下肢缺血性疾病的文献,经质量评价后按一定标准纳入文献,应用RevMan 6.0软件进行分析。运用漏斗图、Begg’s回归分析对各研究间进行发表偏倚估计。结果:共纳入16项研究,包括629例研究对象。Meta分析结果显示,干细胞治疗后TcPO2水平升高(WMD=9.27,95%CI:4.53~14.00,P=0.000),ABI水平升高(WMD=0.13,95%CI:0.19~0.18,P=0.000),温度测定水平升高(WMD=2.75,95%CI:1.92~3.75,P=0.000)。3个Meta分析存在异质性,发表偏倚结果显示,漏斗图对称,Begg’s回归分析结果显示无发表偏倚。结论:干细胞治疗下肢缺血性疾病有效,远期安全性仍需大规模循证医学证实。

Objective： Using Meta analysis comprehensive evaluation of the curative effect of stem cells to treat lower limb ischemic diseases. Methods： Using a computer to retrieve published both at home and abroad literatures about stem cell therapy for lower limb ischemic diseases, after quality evaluation according to certain standard into literature, using RevMan 6. 0 software is ana- lyzed. Using the funnel figure, Begg＇s regression analysis for publication bias estimation between dif- ferent studies. Results： Participants included 16 studies, including 629 cases of the object of study. Meta analysis results show that the stem cells before, during and after the treatment of lower limb ischemic diseases, TcPO2 statistically significant TcPO2 levels after treatment （WMD=9.27,95% CI： 9.27,4.53, P=0.000）. Before and after treatment was statistically difference between ABI, ABI levels after treatment （WME）=0.13, 95% CI：0.13,0.19, P=0.000）. Temperature measurement was statisti- cally difference, temperature measuring levels after treatment（WMD=2.75, 95%C1：2.75,1.92, P=0.000）. Three Meta analysis exists heterogeneity and publication bias results show that the funnel chart is symmetrical, at the same time Begg＇s regression analysis results showed that no publication bias. Conclusion： Stem cells to treat lower limb ischemic diseases effectively, the forward security stil need massive evidence-based medicine.