高海拔地区不同分型的急性期缺血性脑卒中与血清CXCL16和Lp-PLA2水平的相关性研究

Studies on the Relationship Between the Different Subtypes and the Levels of Serum CXCL16 and Lp-PLA2 in Acute Ischemic Stroke at High Altitude

目的:探讨高海拔地区不同分型的急性期缺血性脑卒中与血清CXCL16和Lp-PLA2水平变化之间的相关性。方法:选取2013年8月—2016年2月我科收住院的128例急性期缺血性脑卒中患者作为病例组,对照组为同期性别、年龄与病例组匹配的128例健康体检者。检测空腹血糖、血脂、Lp-PLA2、CXCL16等,并判断缺血性脑卒中类型。结果:LAA组与对照组血清CXCL16[1.42(0.81,2.15)vs 0.82(0.58,1.19)]ng/mL,差异有统计学意义(P<0.05);LAA组与对照组血清Lp-PLA2水平[1.42(0.81,2.15)vs 0.82(0.58,1.19)]ng/mL,差异有统计学意义(P<0.05);SAA组与对照组血清CXCL16水平差异无统计学意义(P>0.05);SAA组与对照组血清Lp-PLA2水平差异无统计学意义(P>0.05);LAA组与SAA组血清CXCL16[1.42(0.81,2.15)vs1.01(0.67,1.30)]ng/mL及Lp-PLA2(12.91±3.57vs 8.66±2.16)ng/mL,差异有统计学意义(P<0.05)。结论:血清CXCL16、Lp-PLA2水平可作为急性缺血性脑卒中患病风险的评估指标,CXCL16、Lp-PLA2水平在LAA患者水平更高。

Objective：The purpose of this study is to investigate the relationship between the different subtypes and the Levels of serum CXCL16 and Lp-PLA2 in acute ischemic stroke at high altitude.Methods：Since August 2013 to February 2016,128 patients with acute cerebral ischemic stroke admitted to the Department of Neurology of Qinghai People＇s Hospital hospitalized were enrolled in this study as case group,while 128 healthy individuals who were matched in gender and age with patients in the case group were enrolled as the control group.Fasting blood glucose,blood lipid,Lp-PLA2 and CXCL16 were measured,and the subtypes of ischemic stroke was determined.Results：The difference in LAA group and control group of serum CXCL16 level[（1.42（0.81,2.15）vs 0.82（0.58,1.19）]ng/mL showed statistically significant（P〈0.05）,which in LAA group and control group of serum Lp-PLA2 level[1.42（0.81,2.15）vs 0.82（0.58,1.19）]ng/mL showed statistically significant（P〈0.05）.And the difference was not statistically significant in SAA group and control group in serum levels CXCL16 group（P〉0.05）,which was not statistically significant in SAA group and control group in serum levels of Lp-PLA2（P〉0.05）.The difference in LAA group and SAA group of serum CXCL16 level[1.42（0.81,2.15）vs 1.01（0.67,1.30）]ng/mL and Lp-PLA2[（12.91±3.57 vs 8.66±2.16）]ng/mL showed statistical significant（P〈0.05）.Conclusion：Serum CXCL16 and Lp-PLA2 levels can be used as an indicator of the risk of acute ischemic stroke,and CXCL16 and Lp-PLA2 levels are higher in patients with LAA.