金华市健康人群乙型病毒性肝炎抗体水平监测分析

Antibody level of hepatitis B among healthy population in Jinhua,Zhejiang province

目的:了解目前金华市部分健康人群乙肝表面抗体(HBsAb)水平。方法:采用分层随机抽样的方法,采集健康人群血清标本1 170份,采用酶联免疫吸附试验检测HBsAb。结果:人群血清中HBsAb阳性率为78.55%,不同性别、户籍人群的抗体阳性率无统计学差异。13个年龄组中抗体阳性率最高的为8月龄~2岁组(100%),最低的为40~50岁组(64.44%),各年龄组阳性率差异有统计学意义(χ~2=64.671,P<0.001)。有免疫史人群和无免疫史人群的抗体阳性率分别为82.53%和74.69%,两者差异有统计学意义(χ~2=9.782,P=0.002)。结论:金华市健康人群HBsAb阳性率高于2006年全国乙肝血清流行病学调查结果;接种乙肝疫苗是预防乙肝的重要手段,要进一步提高乙肝疫苗的接种率;定期开展人群乙肝血清学监测工作。

Objective To explore the surface antibody level of hepatitis B（HBsAb）among healthy population in Jinhua.Methods Healthy people were selected by stratified random sampling method and a total of 1 170 sera samples were collected.The antibody was detected by enzyme-linked immunosorbent assay（ELISA）.Results The antibody positive rate was 78.55% .There was no statistical difference in antibody positive rate among people with different genders and household registrations.The difference was statistically significant in antibody positive rate among 13 age groups（χ^2=64.671,P〈0.001）,with the highest in the group of 8 months to 2 years old（100% ）,and the lowest in the group of 40~50 years old（64.44% ）.There was statistically significant difference between those having vaccine immunization history and those without（χ^2=9.782,P=0.002）,with the antibody positive rates of 82.53% and 74.69% ,respectively.Conclusions The antibody level of hepatitis B surface antigen is higher than the result of national HBsAb epidemiological survey in 2006.Vaccination is an important method for the prevention of hepatitis B,and it is necessary to develop serological monitoring work regularly.