纳米炭淋巴示踪剂在腹腔镜结肠癌根治术中的应用价值

Application value of nano-carbon lymphatic tracer in laparoscopic radical resection of colon cancer

目的评价纳米炭淋巴示踪剂在腹腔镜结肠癌根治术中的示踪作用。方法将46例接受腹腔镜结肠癌根治术的患者按照是否行淋巴结示踪分成淋巴结示踪组23例和对照组23例，淋巴结示踪组在肿瘤周缘注射纳米炭淋巴示踪剂，对照组注射相同剂量氯化钠注射液，记录两组淋巴结清扫数目、大小、时间、转移及黑染等数据。结果淋巴结示踪组每例患者清扫淋巴结数目为（19．6±4．1）枚，明显高于对照组的（14．4±2．0）枚（P〈0．05）；淋巴结示踪组检获前12枚淋巴结时间[（10．1±2．3）min]、淋巴结转移率（40．6％）、小淋巴结检获率（18．2％）均优于对照组[（15．3±3．6）min、32．4％、8．8％，P〈0．05]。结论纳米炭淋巴示踪剂在腹腔镜结肠癌根治术中显示出良好的示踪效果，能够显著提高总淋巴结、转移淋巴结及小淋巴结的检获率，对淋巴结清扫具有重要价值。

Objective To evaluate the tracing effect of nano-carbon lymphatic tracer on laparo- scopic radical resection of colon cancer. Methods Forty-six patients who underwent laparoscopic radical resection of colon cancer were divided into lymphatic tracing group and control group according to whether performing lymphatic tracing, with 23 cases in each group. The lymphatic tracing group was injected with nano-carbon lymph tracer in the periphery of the tumor, the control group was injected with sodium chlo- ride injection of same dose. The number, size, time, transfer and black staining of lymph node dissection in the two groups were recorded. Results The number of resected lymph nodes in lymph tracing group was 19.6±4. 1, which was significantly higher than that in control group （ 14.4 ±2. 0）, P 〈0. 05. The time for detecting the first 12 lymph nodes[ （10. 1 ±2.3 ） mini, lymph node metastasis rate （40. 6% ）, small lymph node detection rate （ 18.2% ） in lymph tracing group were better than those in control group [ （ 15.3 ±3.6 ） min, 32. 4%, 8.8%, P 〈 0.05 ]. Conclusions Nano-carbon lymphatic tracer shows good tracing effect on laparoscopic radical resection of colon cancer, which can significantly improve the detection rate of total lymph nodes, metastatic lymph nodes and small lymph nodes, which is of great val- ue for lymph node dissection.