热毒宁对老年重症肺炎患者肺功能及免疫功能的影响

Effect of reduning on pulmonary function and immune function in elderly patients with severe pneumonia

目的探讨热毒宁对老年重症肺炎患者肺功能及免疫功能的影响。方法选取100例重症肺炎患者为研究对象，随机分成两组，每组50例。对照组予以静脉滴注抗生素等常规综合治疗，观察组在常规综合治疗基础上加用热毒宁。比较两组患者的治疗效果、临床症状消失时间、肺功能指标[用力呼气容积（FEV．）、用力肺活量（FVC）、FEVl实测值占预计值的百分比（FEV1％pre）及FEV。／FVC]及免疫功能指标[免疫球蛋白G（IgG）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）]。结果观察组治疗总有效率为98．00％，高于对照组的82．00％，差异有统计学意义（P〈0．05）。两组治疗前的肺功能指标比较差异未见统计学意义（P〉0．05）；治疗后两组肺功能指标均显著升高，且观察组FEV。、FEV。％pre、FVC等指标升高趋势更为显著，差异有统计学意义（P〈0．05）。两组治疗前各项免疫学指标比较差异未见统计学意义（P〉0．05）；治疗后与对照组相比，观察组IgM、CD3＋、CD4＋、CD8＋、CD4＋／CD8＋等指标水平均较高，而IgA水平较低，差异均有统计学意义（P均〈0．05）。观察组体温恢复时间、咳嗽减轻时间、肺部哕音消失时间及炎症消失时间均短于对照组，差异均有统计学意义（P均〈0．05）。结论老年重症肺炎患者采用热毒宁治疗可显著提高治疗效果，恢复细胞免疫调节功能的平衡，提高肺功能，对改善预后具有积极作用。

Objective To investigate the effects of reduning on pulmonary function and immune function in elderly patients with severe pneumonia. Methods One hundred patients with severe pneu- monia were randomly divided into two groups, with 50 cases in each group. The control group was givenconventional treatment, such as intravenous infusion of antibiotics; and the observation group was given reduning on the basis of conventional treatment. The therapeutic effect, disappearance time of clinical symptoms, pulmonary function indexes [ forced expiratory volume （FEV1）, forced vital capacity （FVC）, actual value/predicted value of FEV1 （FEV1% pre ） and FEVyFVC ], and immune function in- dexes [ immunoglobulin G （IgG）, immunoglobulin A （IgA）, immunoglobulin M （IgM）] in the two groups were compared. Results The total effective rate of treatment in observation group （98.0%） was higher than the that in control group （82.0%）, and the difference was statistically significant （P 〈 0. 05）. Before treatment, there was no statistically significant difference in pulmonary function indexes between the two groups （P 〉 0. 05 ） ; after treatment, pulmonary function indexes significantly increased in both groups, and the increases on FEV1 , FEV1 % pre and FVC in observation group were more remark- able, and the differences were statistically significant （P 〈 0. 05 ）. Before treatment, there was no statis- tically significant difference in immune function indexes between the two groups （ P 〉 0. 05） ; after treat- ment, levels of IgM, CD3＋ , CD4 ＋ , CD8 ＋ , CD4 ＋/CD8 ＋ in observation group were higher than those in control group, however, the IgA level was lower in observation group, and the differences were statistical- ly significant （ all P 〈 0. 05 ）. Recovery time for body temperature, time for cough alleviation, disappea- ring time for pulmonary tales and inflammations in observation group were shorter than those in control group, the differences were statistically significant （P 〈 0. 05 ）. Conclusions For elderly patients with severe pneumonia, reduning can significantly improve the therapeutic effect and lung function, and reho- bilitate balonce of cellular immunity, thus produce a positive effect on improvement of prognosis