靶向抗肿瘤药物致高血糖发生机制的研究进展

Research progress on the mechanism of anti-tumor drugs causing hyperglycemia

肿瘤是全球第二大死亡原因，新一代肿瘤治疗进展较快，如靶向肿瘤治疗。与常规化疗一样，靶向药物可抑制癌细胞，增加癌细胞死亡并限制癌细胞扩散。靶向治疗对多种疾病（包括肺癌、结肠直肠癌、乳腺癌、淋巴瘤和白血病）有较好的疗效。多种靶向药物有不同于传统化疗、放疗的不良反应，如可诱发治疗性相关血糖升高。通过药物纳米封包改变给药途径为探究二甲双胍的抗癌作用提供了可能的解决方案。本文综述了抗肿瘤的代表性靶点（mTOR、IR／IGFR、EGFR和P13K／AKT）药物致血糖升高发生机制的研究进展。

Tumor is the second leading cause of death in the world, and new generations of tumor treatment progTesses fast, for example targeted tumor therapy. Targeted drugs, similar to conven- tional chemotherapy, can inhibit cancer cells, increase cancer cell death and limit cancer cell prolifera- tion. Targeted therapy have a good effect on a variety of diseases, such as lung cancer, colorectal canc- er, breast cancer, lymphoma and leukemia. Many targeted drugs have different side effects from tradi- tional chemotherapy and radiotherapy, for example it can induce therapeutic relevance hyperglycemia. The route of administration is changed with drugs encapsuled in targeted nanoparticles and it provides ac- cessibility to investigate the anti-cancer effect of Metformin. This review summarized the research progress of machanism of anti-tumor representative targets drugs （mTOR, IR/IGFR, EGFR and PI3K/AKT） on inducing blood suger increasing.