鼠神经生长因子治疗Ramsay-Hunt综合征的疗效观察

Therapeutic effect of mouse nerve growth factor for Ramsay-Hunt syndrome

目的观察鼠神经生长因子治疗Ramsay-Hunt综合征的疗效。方法回顾性分析2010年1月~2013年12月收治的23例Ramsay-Hunt综合征患者,随机分成两组,对照组(12例)予以常规抗病毒激素等支持对症处理,观察组(11例)在对照组治疗基础上予以鼠神经生长因子治疗。治疗前后分别对比两组患者H-B面神经功能分级、起效时间、平均疗程,测定面神经传导速度。结果治疗后观察组较对照组在面神经功能分级、起效时间、平均疗程以及面神经传导速度上均有改善,差异具有统计学意义(P<0.05)。结论鼠神经生长因子治疗Ramsay-Hunt综合征疗效好,临床上应尽早诊断及时治疗。

Objective To observe the therapeutic effect of mouse nerve growth factor for Ramsay-Hunt syndrome. Methods Clinical data of 23 patients suffering from Ramsay-Hunt syndrome from Jan 2010 to Dec 2013 were analyzed retrospectively. They were randomly divided into observation group （n = 11 ） and control group （n = 12）. The patients of the control group were given conventional therapy of antiviral drugs and steroid hormone, while those of the observation group received additional treatment of mouse nerve growth factor on the basis of the control group. Their therapeutic effects were evaluated with House-Brackmann scale of facial nerve function, initial effect time, average course of treatment and facial nerve conduction velocity. The difference of the therapeutic effect between the two groups was compared. Results After treatment, the House-Brackmann scale and conduction velocity of facial nerve of the observation group were more significant improved than those of the control group. The initial effect time and average course of the observation group were shorter than those of the control group. All the differences between the two groups were statistically significant （ all P 〈 0.05 ）. Conclusion Mouse nerve growth factor is effective for the treatment of Ramsay-Hunt syndrome. This disease should be diagnosed as soon as possible and timely treatment should be given.