葡萄膜炎患者焦虑抑郁状况及其对生命质量的影响

The impact of anxiety and depression on quality of life in patients with uveitis

目的调查葡萄膜炎患者焦虑抑郁情况，并分析其生命质量的影响因素。方法在2015年9月至2016年3月，对130例葡萄膜炎患者通过面对面的方式进行问卷调查，问卷包括一般社会人口学问卷、视功能损害眼病生命质量量表、焦虑自评量表、贝克抑郁自评量表。结果回收有效问卷126份，有效回收率96.9%（126/130）。葡萄膜炎患者焦虑自评量表得分为（43.49 ± 7.20）分，贝克抑郁自评量表得分为（7.50 ± 6.60）分，均低于标准分，抑郁发生率为28.6%（36/126），焦虑发生率仅为14.3%（18/126）。焦虑自评量表得分与生命质量的精神心理维度得分呈负相关（r=-0.310，P〈0.01），贝克抑郁自评量表得分与生命质量平均得分、4个维度及总生命质量得分呈负相关（r=-0.534--0.240，均P〈0.01）。多元线性回归分析显示,生命质量受抑郁程度、视力损伤程度、教育程度、性别影响（P〈0.05）。结论葡萄膜炎患者抑郁、焦虑的发生率较低，得分均低于标准分。抑郁程度、视力损伤程度、教育程度、性别是影响葡萄膜炎患者生命质量的因素。

ObjectiveTo describe the status of anxiety and depression in patients with uveitis, and to explore the related factors of quality of life.MethodsA total of 126 uveitis patients from September 2015 to March 2016 were investigated with the General Social Population Questionnaire, Life Quality for Diseases with Visual Impairment Scale, Self-rating Anxiety Scale and Beck Depression Inventory. ResultsThere were 126 valid questionnaires, and the effective recovery rate was 96.9% （126/130）. The score of Self-rating Anxiety Scale in uveitis patients was （43.49±7.20） points which lower than the standard mark standardized score, and 14.3% （18/126）of patients were diagnosed with anxiety. The score of Beck Depression Inventory in uveitis patients was （7.50±6.60） points which lower than the standard mark standardized score, 28.6% （36/126）of patients were diagnosed with depression. The Self-rating Anxiety Scale scores and psychological dimensions of quality of life was negatively correlated （r=-0.310, P〈0.01）, and the Beck Depression Inventory scores and the average score of the quality of life, the 4 dimensions and total score of quality of life was negatively correlated（r=-0.534--0.240, all P〈0.01）. The multiple linear regression analysis showed that the related factors of quality of life were score of depression, vision loss, education and gender（P〈0.05）.ConclusionsThe incidence of depression and anxiety are both lower in patients with uveitis than general population. The status of quality of life is related to the score of depression, vision loss, education and gender.