胰腺脂肪含量与2型糖尿病的相关性

Correlation between pancreatic fat content and type 2 diabetes mellitus

目的 探讨胰腺脂肪含量与2型糖尿病（T2DM）之间的关系.方法2017年1~6月纳入60例初诊T2DM患者（糖尿病组）及64例非糖尿病健康受试者（对照组）,测量身高、体重,计算体质指数（BMI）,测定空腹血糖（FPG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbA1c）及空腹胰岛素（FINS）水平,计算稳态模型胰岛素抵抗指数（HOMA-IR）及稳态模型β细胞功能指数（HOMA-β）.应用磁共振成像Dixon技术对受试者的胰腺进行扫描,测量、计算胰腺脂肪含量分数（PFVF）.应用t检验比较两组间数据,应用Pearson或Spearman检验进行相关性分析.结果 糖尿病组及对照组的PFVF分别为（9.6±4.1）%、（6.6±2.8）%,差异有统计学意义（t=4.745,P〈0.05）.相关性分析表明,PFVF与BMI、FPG、TG均低度相关（分别为r=0.386、0.358、0.323,均P〈0.05）,PFVF与HDL-C（r=-0.339,P〈0.05）呈负相关,而PFVF与TC、LDL-C、HbA1c、FINS、HOMA-IR、HOMA-β均未见相关.结论 胰腺脂肪含量增加可能对T2DM的发病有重要意义.

Objective To investigate the correlation between pancreatic fat content and type 2 diabetes mellitus（T2DM）.Methods From January to June 2017,60 patients with newly diagnosed type 2 diabetes mellitus and 64 non-diabetic healthy subjects were enrolled into diabetes group or control group, respectively. Various indexes were measured, including height, weight, body mass index （BMI）, fasting plasma glucose（FPG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）,triglyceride（TG）, low density lipoprotein cholesterol （LDL-C）, glycosylated hemoglobin （HbA1c） and fasting insulin （FINS）. Insulin resistance （IR） index and β cell function index were evaluated with homeostasis model assessment （HOMA）.The pancreas was scanned with magnetic resonance imaging Dixon technique,then the pancreatic fat volume fractions （PFVF） was measured and calculated. The data between these two groups were compared with t test, and the correlation analysis was evaluated with Pearson or Spearman test. Results The PFVF in diabetic group was higher than that in control group（9.6%±4.1% vs 6.6%±2.8%,t=4.745,P〈0.05）. The correlation analysis showed that PFVF was positively correlated with BMI （r=0.386, P〈0.05）, FPG（r=0.358,P〈0.05）and TG（r=0.323,P〈0.05）,meanwhile negatively correlated with HDL-C（r=-0.339, P〈0.05）. However, PFVF had no correlation with TC, LDL-C, HbA1c, FINS, HOMA-IR and HOMA-β. Conclusion Accumulation of fat content in pancreas may play an important role in the pathogenesis of T2DM.