106例药品不良反应报告分析

Analysis of 106 Adverse Drug Reaction Cases

目的分析某院药品不良反应发生的规律与特点,为临床安全用药提供参考。方法采用回顾性研究方法对某院2014年1月~2016年1月上报的106例药品不良反应报告进行分析。结果 106例不良反应病例中,男性44例(41.51%),年龄分布以40~50岁的病例最多(24.53%);静脉滴注(57.55%)为发生不良反应最多的给药途径;中药制剂(18.37%)为发生不良反应最常见的药品种类,抗菌药物(21.70%)发生不良反应的例数最多;左氧氟沙星(3.77%)为发生不良反应最多的药物;临床表现主要以皮肤及附件损害最为常见,占30.07%;药品不良反应级别主要为一般(59.43%)。对原患疾病影响不明显的有103例(97.17%);治疗转归治愈的有30例(28.30%),转归良好的有76例(71.70%);不良反应主要由临床医生报告(86.79%)。结论药品不良反应的发生与给药途径、药品种类等多种因素有关,临床应重视药品不良反应的上报及总结,为临床安全用药提供指导。

OBJECTIVE To analyze the regularity and characteristics of adverse drug reaction （ADR） cases reported in a hospital, so as to provide reference for clinical safe medication. METHODS A total of 106 ADR cases in a hospital from January 2014 to January 2016 were analyzed by retrospective method. RESULTS Among the 106 cases of ADR reports, 44 cases were occurred in male patients（41.51%）. Patients at the age of 40-50 years had the highest incidence rates （24.53%）. ADRs were mainly caused by intravenous administration（ 57.55% ）. A total of 18.37% cases were induced by traditional Chinese medicine preparation. Drug-related kinds of antibiotics up to 21.70% cases, 3.77% cases involved with levofloxacin. Main clinical manifestations were lesions of skin and its appendages, accounted for 30.07%. The level of major ADRs was general （59.43%） , 103 ADR cases （97.17%） had no obvious influence on the primary disease, 30 cases （28.30%） were cured and 76 cases （71.70%） were improved. Among these, 86.79% of ADR cases were reported by clinicians. CONCLUSION ADRs are related to drug administration, drug types and other factors, physicians should pay more attention to the report and summary of adverse reactions, so as to ensure the safety of drug use.