降血脂药的前处理及检测技术研究进展

Update advance in pretreatment and detection of lipid regulators

近10年,高血脂患者迅速增多刺激了降血脂药物的研究和开发,此类药物检测技术的研究也逐渐成为科研领域的研究热点。基于此,本文经过广泛的文献调查,简要阐述了此类药物的样品前处理及检测方法,归纳总结此类药物在各类基质中的研究现状,以期为后续开展相关研究提供参考。前处理方法包括:分散液—液微萃取(DLLME)、固相萃取(SPE)、固相微萃取(SPME)、基质固相分散(MSPD)、超临界流体萃取(SFE)、超声辅助萃取(UE)等,检测方法主要有气质联用技术、高效液相方法、液质联用技术等。

The rapid increase of hyperlipidemia patients has stimulated the development of lipid regulators in recent ten years. The study on the detection technology of these drugs has gradually become a hotspot in the field of scientific research. We summarized method of pretreatment and detection,as well as present research situation in various matrices in order to provide reference for the follow-up research. The major pretreatment method include liquid-liquid microextraction（ DLLME）,solid phase（ SPE）,solid phase microextraction（ SPME）,matrix solid phase dispersion（ MSPD）,supercritical fluid extraction（SFE） ultrasonic assisted extraction（ UE） and so on. The main detection method are GC-MS, liquid chromatography technology and so on.