强脉冲光联合果酸治疗面颈部毛囊性红斑黑变病的疗效及安全性评价

Clinical Efficacy and Safety of Joint Application of Intense Pulsed Light and Alpha Hydroxy Acids in Treating Erythromelanosis Follicularis Faciei Et Colli

目的评价强脉冲光(Intense pulsed light,IPL)联合果酸(alpha hydroxy acids,AHAs)治疗面颈部毛囊性红斑黑变病(Erythromelanosis follicularis faciei et colli,EFFC)的疗效和安全性。方法 EFFC患者57例,随机分为两组。A组患者29例,采用不同浓度的AHAs联合IPL治疗,IPL治疗波长540 nm,每月1次;AHAs治疗,每3周1次,共4次。B组患者28例,仅给予IPL治疗,疗程同A组。分别于治疗第2、4次后评价两组疗效和安全性。结果 A组在第2次和第4次治疗后的总有效率分别为65.5%、86.2%;B组总有效率依次为46.4%、60.7%。两组患者2次治疗后疗效比较,差异无统计学意义(P>0.05);两组患者4次治疗后比较,差异具有统计学意义(P<0.05)。不良反应:A组5例;B组2例,两组患者不良反应比较,差异无统计学意义(P>0.05)。治疗后1个月随访,两组无一例复发。结论 IPL联合AHAs治疗EFFC疗效好、不良反应少,可减少治疗次数,降低治疗费用。

Objective To observe the efficacy and safety of joint application of intense pulsed light （IPL） and alpha hydroxy acids （AHAs） in treating Erythromelanosis follicularis faciei et colli （EFFC）. Methods Totally 57 patients with EFFC were divided randomly into two groups： Group A （29 cases） and Group B （28 cases ）. The patients in Group A were treated with AHAs once every three weeks 4 times in total and IPL 540 nm once each month. The patients in Group B were given only IPL and the course was the same as that of Group A. The clinical efficacy and safety of two groups were observed respectively after twice and 4 times of treatment. Results The efficacy of Group A reached 65.5 % and 86. 2% after twice and 4 times of treatment respectively, while that of Group B being 46.4% and 60. 7% respectively. As to total efficacy rate, the difference between two groups after twice of treatment was not sta- tistically significant （ P 〉 0. 05 ）, but remarkable （ P 〈 0.05 ） after four times of the treatment. Adverse reactions occurred to 5 patients in Group A and 2 patients in Group B and the difference between two groups was not statistically significant （P 〉 0. 05）. Recurrence of EFFC or occurrence of secondary adverse reactions was observed in neither group during the follow-up performed I month after the treat- ment. Conclusions Featuring good efficacy and less adverse reaction, combined application of IPL and AHAs will reduce the number as well as cost of the treatment of EFFC.