脑梗死患者出现缺血性脑白质病变的危险因素分析

Analysis of the risk factors of ischemic brain white matter lesions in cerebral infarction patients

目的:探讨影响脑梗死患者出现缺血性脑白质病变的危险因素。方法:选取2016年5月至2017年5月收治的100例单纯脑梗死患者为对照组,选取同期100例脑梗死合并缺血性脑白质病变患者为观察组,通过单因素分析和多因素logistic回归,分析脑梗死患者出现缺血性脑白质病变的危险因素。结果:多因素Logistic回归分析显示脑梗死发病史、高血压病史(OR=1.04,95%CI:0.234~2.568)、空腹血糖(blood glucose,BG)(OR=0.784,95%CI:1.239~3.547)、血浆同型半胱氨碱(homocysteine,Hcy)(OR=1.14,95%CI:0.998~1.897)、血清碱性磷酸酶(alkaline phosphatase,ALP)(OR=1.20,95%CI:0.567~2.584)为脑梗死合并缺血性脑白质病变的独立危险因素(P<0.05)。结论:脑梗死发病史、高血压病史、BG、Hcy、ALP为脑梗死合并缺血性脑白质病变发生的危险因素。

Objective： To investigate the risk factors of ischemic brain white matter lesions in cerebral infarction patients. Methods： 100 cases of patients with cerebral infarction treated in our hospital from May 2016 to May 2017 were selected as the control group, and 100 patients with cerebral infarction combined with ischemic brain white matter lesions were selected as the observation group. The risk factors of ischemic brain white matter lesions in cerebral infarction patients were analyzed by single factor and logistic regression analysis. Results： The history of cerebral infarction, the history of hypertension （ OR = 1.04,95 % C1：0. 234 - 2. 568 ）, BG （ OR = 0. 784,95 % CI ： 1. 239 - 3. 547）, Hcy （ OR = 1.14,95 % C1：0. 998 - 1. 897） and ALP （ OR = 1.20,95 % CI：0. 567 - 2. 584） were independent risk factors for cerebral infarction combined with ischemic brain white matter lesions （ P 〈 0.05 ）. Conclusion： The history of cerebral infarction, the history of hypertension, BG, Hcy and ALP are risk factors for cerebral infarction combined with ischemic brain white matter lesions.