依达拉奉对老年腰椎间盘突出患者术后认知功能障碍的影响

Effects of edaravone on postoperative cognitive dysfunction in elderly patients receiving lumbar disc herniation surgery

目的:通过采用简易精神状态检查量表(MMSE)对接受全麻腰椎间盘突出手术治疗的老年患者的认知功能进行评分,从而评价依达拉奉对腰椎间盘突出老年患者术后早期认知功能障碍的影响。方法:2017年1月至5月在唐山市工人医院收治的腰椎间盘突出患者择期行腰椎后路椎间盘摘除术的患者40例,年龄65~75岁,随机分为观察组和对照组,每组各20例;两组患者均采用全身麻醉,观察组患者于术前30 min静脉输注依达拉奉30 mg,对照组患者给予等量生理盐水,分别于术前24 h及术后6 h、24 h、48 h、72 h用简易精神状态检查量表评估所有患者的认知功能。结果:两组患者术后6 h、24 h、48 h的MMSE评分均较术前24 h降低(P<0.05),观察组术后6 h、24 h、48 h的MMSE评分均高于对照组患者(P<0.05)。两组患者术后72 h的MMSE评分均恢复至术前水平,差异无统计学意义(P>0.05)。结论:老年腰椎间盘突出患者行腰椎后路椎间盘摘除术后认知功能下降,依达拉奉能提高患者早期MMSE评分,改善术后早期认知功能。

Objective：To explore and evaluate the effect of edaravone on early postoperative cognitive dysfunction in elderly patients by adop- ting Mini - Mental State Examination （MMSE） scale for cognitive function score of elderly patients receiving lumbar disc herniation general anes- thesia surgery treatment. Methods：40 patients from 65 to 75 years old with lumbar disc herniation who underwent posterior excision of protruded lumbar disc in Tangshan City Workers Hospital from January to May in 2017 were selected and randomized into experimental group （group A） and control group （ group B）, 20 cases in each group. Both groups were treated with general anesthesia. In group A edaravone 30 mg was intravenously injected 30 minutes before operation, and group B received the same volume of saline. MMSE was used to assess the patients＇cognitive function at 24h before operation and 6h,24h ,48h and 72h after operation. Results ： MMSE scores 6h ,24h and 48h after operation in two groups were decreased significantly compared with that 24h before operation （ P 〈 0.05 ）. MMSE scores 6h,24h and 48h after operation in group A were higher than those in group B （ P 〈 0.05 ）. There was no significant difference in MMSE scores 72h after operation between the two groups （ P 〉 0.05 ）. Con- clusion ： The cognitive function of elderly patients receiving lumbar disc herniation surgery treatment was significantly decreased, and edaravone can significantly improve the early MMSE score and their early cognitive function after operation.