双歧杆菌治疗儿童手足口病及对血清IL-6、IL-1β和TNF-α水平的影响

Effects of Bifidobacterium in the treatment of children with hand-foot-and-mouth disease and influence on serum levels of IL-6,IL-1β and TNF-α

目的:探讨双歧杆菌在治疗儿童手足口病(hand-foot-and-mouth disease,HFMD)中的效果。方法:选取2014年1月至2017年1月确诊并进行治疗的160例儿童HFMD患者为研究对象,随机分为观察组和对照组,每组80例,对照组采取常规治疗方式,观察组在常规治疗的基础上加用双歧杆菌,治疗7 d后对两组患儿病情进行评估,对比治疗有效率,患儿退热、疱疹结痂、口腔溃疡愈合时间,两组患儿治疗前后血清白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)水平。结果:观察组治疗总有效率(95.0%)高于对照组的治疗总有效率(80.0%)(χ~2=5.061,P=0.01);观察组患儿退热、疱疹结痂、口腔溃疡愈合时间均短于对照组(P<0.05)。治疗前,两组患儿血清因子水平比较,差异无统计学意义(P>0.05);治疗后,两组血清因子水平均有下降(P<0.05),且观察组下降程度较对照组高(P<0.05)。结论:使用双歧杆菌可以提高治疗的有效率,并降低炎性因子水平,有利于疾病的愈合,该方法切实有效,值得临床推广。

Objective：To study the effects of Bifidobacterium in the treatment of children with hand -foot -and -mouth disease （HFMD）. Methods ：160 cases of children with HFMD diagnosed and treated in our hospital from January 2014 to January 2017 were randomly divided into experimental group and control group, 80 eases in each group. The control group was treated with conventional treatment, and the experimental group was treated with Bifidobacterium on the basis of the control group. After 1 week of treatment, the states of patients were evaluated. The treatment efficiency and the time of defervesce, herpes scab and oral ulcer healing of the two groups were compared, and the IL -6, IL -1β and TNF -α levels were compared between the two groups before and after treatment. Results： The total efficien- cy in the control group was 79.7 %, the total efficiency in the experimental group was 95.0 %, and the difference was statistically significant （ X^2 = 5. 061, P = 0. 01 ）. The time of defervesce, herpes scab and oral ulcer healing in the experimental group were shorter than those in the control group （ P 〈0.05）. Before treatment, there was no significant difference of serum factor levels between the two groups （ P 〉 0.05 ）. After treatment, the serum factor levels in the two groups were de- creased, and the decrease degree in the experimental group was significantly bigger than that in the control group （ P 〈0.05 ）. Conclusion：The use of Bifidobacteri- um can improve the efficiency of treatment, and effectively reduce the level of inflammatory factors, which is conducive to the disease healing. The method is effective and worthy of clinical promotion.