血液透析联合血液灌流对CKD-MBD患者矿物质-骨代谢状况的影响

Effect of hemodialysis combined with hemoperfusion on mineral and bone metabolism in CKD-MBD patients

目的:探讨血液透析联合血液灌流对矿物质-骨代谢异常(chronic kidney disease-mineral and bone disorder,CKD-MBD)患者矿物质-骨代谢状况的影响。方法:选取2014年7月至2017年5月180例CKD-MBD患者,随机分为观察组和对照组,每组90例,观察组患者采用血液透析联合血液灌流模式,对照组患者采用血液透析模式,对比两种方法的治疗效果。结果:观察组患者的整体治疗有效率为94.4%,高于对照组的80.0%(P<0.05);观察组患者的血钙值高于对照组(P<0.05),血磷、全段甲状旁腺素值低于对照组(P<0.05);两组患者均未发生严重不良反应。结论:CKD-MBD患者的治疗中采用血液透析联合血液灌流方式,能够提高整体治疗有效率,改善患者的血清指标且不会增加不良反应发生率。

Objective：To investigate the effect of hemodialysis combined with hemoperfusion on mineral and bone metabolism in CKD - MBD patients, nethods：180 cases of patients with CKD - MBD from July 2014 to May 2017 in our hospital were selected and randomly divided into ob- servation group and control group, 90 cases in each group. The observation group was treated with hemodialysis combined with hemoperfusion, and the control group was treated with hemodialysis. The effects of the two methods were compared. Results：The overall effective rate in the observation group was 94.4 %, which was higher than that in the control group （ 80.0 % ）, and the difference was statistically significant （ P 〈 0.05 ）. The blood calcium value in the observation group was higher than that in the control group, and the values of serum phosphorus and intact parathyroid hormone were lower than those in the control group （ P 〈 0.05 ）. There were no serious adverse reactions in the two groups. Conclusion ： Hemodi- alysis combined with hemoperfusion in the treatment of CKD - MBD can improve the overall efficiency of treatment and the serum parameters of pa- tients without the increase of the incidence of adverse reactions.