侵袭性葡萄胎患者化疗前后血HCG与IL-6水平的相关性

Correlation of HCG and IL-6 in patients with invasive hydatidiform mole before and after chemotherapy

目的:探讨侵袭性葡萄胎患者化疗前后血绒毛膜促性腺激素(HCG)与白介素-6(IL-6)水平的变化及其相关性。方法:随机选取2013年1月至2016年12月侵袭性葡萄胎患者65例为研究对象,所有患者均给予氟尿嘧啶维持3个疗程的化疗,采用自身对照研究方法,检测化疗前和化疗结束后患者血清HCG与IL-6水平,比较HCG与IL-6的相关性。结果:不同阶段患者血清HCG水平与IL-6水平比较差异具有统计学意义(P<0.05),化疗后血清HCG水平与IL-6水平逐渐降低且化疗后第24 d低于其他时间点(P<0.05);化疗后病灶缩小或消失,血清HCG呈现逐渐降低至正常的趋势,炎性因子IL-6亦逐渐降低,相关分析显示两者存在正相关(r=0.87,P<0.05)。结论:化疗后可有效降低HCG和炎性因子IL-6水平,两者具有正相关,可作为判断化疗疗效和患者疾病转归的重要指标。

Objective：To study the changes of HCG and IL - 6 in patients with invasive hydatidiform mole before and after chemotherapy, and the correlation between them. Methods： 65 cases of patients with invasive hydatidifoim mole from January 2013 to December 2016 were ran- domly selected as research objects. All the patients were given three courses of chemotherapy, and serum HCG and IL - 6 levels before and after chemotherapy were detected and the correlation between them was compared. Results：There were significant differences between the serum HCG and IL - 6 levels at different stages （ P 〈 0.05）. After treatment, the serum HCG and IL - 6 levels were gradually reduced （ P 〈 0.05）. The lesions shrank or disappeared, and the serum HCG reduced to the normal; the IL - 6 level was reduced, and there was significantly positive corre- lation （ r = 0.87, P 〈0.05）. Conclusion： After chemotherapy, the HCG and IL - 6 levels can be effectively reduced, and HCG is positively correlated with IL - 6. Both of them can be used as an important indicator for chemotherapy efficacy and disease outcome in patients.