受体酪氨酸激酶Eph基因在甲状腺癌中表达及作用的研究进展

Research progress on the expression and function of receptor tyrosine kinase Eph gene in thyroid carcinoma

甲状腺肿瘤是一种最常见的内分泌肿瘤,近年流行病学研究表明其发病率呈快速上升趋势。促红细胞生成素产生肝细胞(Eph)基因作为最大的酪氨酸激酶受体家族,被发现参与多种生理病理过程,并且其在肿瘤发生中的作用引起越来越多的关注。Eph受体在人类许多恶性肿瘤中有过表达现象,与肿瘤的生长、侵袭、转移和血管生成有关。研究发现,受体Eph在甲状腺癌中的表达水平明显增加,其在甲状腺癌的发生、发展和侵袭转移中起着重要作用,在甲状腺癌的早期诊断和靶向治疗方面前景广阔。

Thyroid tumor is one of the most common endocrine tumors.Recent epidemiological studies show that the incidence of thyroid carcinoma is increasing rapidly.Erythropoietin producing hepatocyte（Eph） gene as the largest family of tyrosine kinase receptors,is found to be involved in many physiological and pathological processes,and its role in tumorigenesis is attracting more and more attention.Eph receptors are over-expressed in many human malignancies and are associated with tumor growth,invasion,metastasis,and angiogenesis.Research shows that the expression level of Eph receptor in thyroid carcinoma is significantly increased,which plays an important role in the occurrence,development and metastasis of thyroid carcinoma and has broad prospects for early diagnosis and treatment of thyroid carcinoma.