活血利水方治疗脾肾阳虚兼瘀血型PNS的临床疗效观察

Clinical Observation of Activate Blood-Drain water Formula on the Treatment of Spleen-Kidney Yang Deficiency and Blood Stasis Syndrome Type of Primary Nephrotic Syndrome

目的:探讨活血利水方治疗脾肾阳虚兼瘀血型原发性肾病综合征(Primary Nephrotic Syndrome,PNS)的临床疗效。方法:研究包括对照组29例、治疗组30例,共59例患者。两组病例患者均给予糖皮质激素、降脂抗凝药的常规基础治疗,对照组加服昆仙胶囊,治疗组加服自拟中药汤剂活血利水方,疗程8周。观察患者治疗的总疗效、中医证候积分变化,以及24 h尿蛋白定量、血浆白蛋白、总胆固醇、甘油三脂、凝血功能指标的变化。结果:治疗后治疗组总有效率93.33%优于对照组的89.66%(P<0.05);治疗组与对照组的中医证候疗效,中医证候积分差异有统计学意义(P<0.05);治疗组在减少尿蛋白,提高血浆白蛋白,降低血脂,改善肾病综合征高凝状态均优于对照组(P<0.05)。结论:活血利水方对脾肾阳虚兼瘀血型PNS有明显的疗效,能显著改善患者的临床症状和体征,减少尿蛋白的漏出,提升血淸白蛋白,改善其高凝状态和高脂血症。

Objective： Objective To investigate the therapeutic effect of Activate blood-Drain water formula on spleen-kidney yang deficiency and blood stasis syndrome type of primary nephrotic syndrome（ PNS）.Methods： 59 patients including 30 cases in treatment group and 29 cases in control group.Both of groups were treated with glucocorticoids,lipid-lowering drugs and anticoagulant therapy.Moreover,the treatment group take Activate blood-Drain water Formula,control group take Kunxian Capsule.The treatment is 8 weeks.Observation of the two groups of treatment total effective、TCM syndrome scoring and 24 h ruprv、serum albumin（ Alb） 、cholesterol（ TC） 、triglyceride（ TG） 、activated partial thrombin time（ APTT） 、fibrinogen（ FIB）.Results： After 8 weeks,the treatment group＇s total curative effects and TCM syndrome score are better than control group（ P〈0.05）; The treatment group were also better than the control group at reducing urinary protein,improving the blood plasma albumin,reducing blood fat and improving nephrotic syndrome high coagulation state（ P〈0.05）.Conclusion： Activate blood-Drain water Formula on the treatment of spleen-kidney yang deficiency and blood stasis syndrome type PNS has a significantly effect.