Rab1A与肿瘤发生发展的研究进展

Research advances of Rab1A in the development of cancer

Rab1A是RAB家族的一员,是一种小三磷酸鸟苷(GTP)酶,是哺乳动物雷帕霉素靶蛋白复合体1(mTORC1)的激活因子,已经被证实参与调节内质网至高尔基体的囊泡运输。随着Rab1A研究的不断深入,很多学者发现Rab1A蛋白还参与信号传导、细胞迁移以及自体吞噬的调节。同时Rab1A异常表达也与一些临床疾病的发生发展有关,如帕金森氏病、原发性心肌病及阿司匹林加重性呼吸道疾病等。而近年来人们逐渐开始关注Rab1A在肿瘤发生发展中的作用,在包括舌癌、乳腺癌、肺癌、肝癌、结直肠癌、胃癌及子宫颈癌等多种恶性肿瘤中Rab1A均有不同程度的高表达,且在肿瘤的发生发展中扮演着重要角色。文章就Rab1A在肿瘤发生发展及信号通路等方面的研究进展进行综述。

Rab1A is a member of the RAB family as a small GTPase and a mammalian target of rapamycin complex 1 （mTORC1） Activator, which has been well established to mediate vesicular trafficking from the endoplasmic reticulum （ER） to the Golgi apparatus. With increasingly deep research of Rab1A, many researchers discover that Rab1A protein is also involved in mediating signal transduction, cell migration and regulation of autophagy. Meanwhile, aberrant expression of Rab1A has been linked to a range of human diseases as well, including Parkinson’s disease, cardiomyopathy, and aspirin-exacerbated respiratory disease. Recently Rab1A research has gradually shifted to its role in occurrence and development of tumor, and researchers also discover that Rab1A was abnormally expressed in many malignant tumors such as tonguesquamous carcinoma, breast cancer, human lung cancer, hepatocellular carcinoma, colorectal cancer, gastric cancer and cervical cancer. Besides that, over expression of Rab1A plays a significant role in the progression of different tumors. This article summarizes the research progress of Rab1A intumor development and signaling pathways.