葡萄糖转运蛋白1在泌尿系肿瘤中的研究进展

Research progress of GLUT1 in urinary tumor

葡萄糖转运蛋白1(GLUTs)是介导哺乳动物细胞葡萄糖转运的主要载体,其亚型GLUT1在体内葡萄糖转运体中分布最为广泛。研究表明,GLUT1在泌尿系肿瘤如肾癌、前列腺癌、膀胱癌、肾母细胞瘤中异常高表达,导致细胞内葡萄糖摄取增加,与肿瘤的发生、演变、侵袭、预后及耐药性密切相关。GLUT1作为肿瘤治疗的新靶点现已引起了广泛关注。文章主要就GLUT1在泌尿系肿瘤中的表达及其作用机制的研究进展进行综述,旨在为肿瘤的靶向分子治疗及预后提供新的切入点。

Glucose transporters protein （GLUTs） is the main carrier of glucose transport in mammalian cells, in which GLUT1 is the most widely distributed in glucose transporter in vivo. Studies have shown that GLUT1 has abnormally high expression in urinary tract tumors such as renal cell carcinoma, prostate cancer, bladder cancer and nephroblastoma,cleading to increased intracellular glucose uptake, which is closely related to tumor occurrence, evolution, invasion, prognosis and drug resistance. As a new target of tumor therapy, GLUT1 has attracted extensive attention. This review summarizes the recent advances on the expression of GLUT1 in tumor and its mechanism, which can provide a new perspective for the treatment and prognosis evaluation of tumor.