吲哚氰绿清除试验在乙型肝炎肝硬化诊断中的临床意义

Clinical significance of indocyanine green clearance test in the diagnosis of hepatitis B liver cirrhosis

目的探讨吲哚氰绿清除试验在乙型肝炎肝硬化诊断中的临床意义。方法回顾性分析2016年6月~2017年7月在青岛市第六人民医院住院的275例慢性乙型病毒性肝炎患者(慢性乙型肝炎组)和306例乙型肝炎肝硬化(乙型肝炎肝硬化组)患者的临床资料。对两组患者进行腹部超声、吲哚氰绿清除试验和肝脏瞬时弹性硬度检测。结果乙型肝炎肝硬化组R15、T1/2和E较慢性乙型肝炎组明显升高(P<0.05),而K值显著降低(P<0.05)。K值及CAP值与肝硬化程度间呈显著负相关(r=-0.672、-0.826,均P<0.05),R15值与肝脏硬化程度呈显著正相关(r=0.891,P<0.05)。结论吲哚氰绿清除试验有助于评估肝脏硬度,作为Fibroscan的补充,可能成为推断肝纤维化的新指标和方法。

Objective To study the clinical significance of indocyanine green excretion test in the diagnosis of patients with hepatic B liver cirrhosis. Methods The clinical data of 275 patients with hepatitis B （chronic hepatitis B group） and 306 patients with hepatic B liver cirrhosis （hepatitis B liver cirrhosis group） in the Sixth People＇s Hospital of Qingdao from June 2016 to July 2017 was analyzed retrospectively. The indole cyanogen green （ICG） discharge tested, liver stiffness detection and abdominal ultrasonography were carried out in the two groups. Results Compared with chronic hepatitis B group, T1/2,R15 value and E value was increased in hepatic B liver cirrhosis group, and the K value was decreased, the differences were statistically significant （P 〈 0.05）. K value and CAP value were negatively correlated with the degree of liver sclerosis （r = -0.672, -0.826, all P 〈 0.05）, R15 value was positively correlated with the degree of liver sclerosis （r = 0.891, P 〈 0.05）. Conclusion Indocyanine green test is helpful to evaluate the liver sclerosis, as a supplement to Fibroscan, and can be the new indication and method to investigate the degree of liver sclerosis.