丹参川芎嗪注射液对缺血性脑卒中患者同型半胱氨酸、高敏C反应蛋白和血脂水平的影响及疗效观察

Clinical observation and effect of Salvia Tetramethylpyrazine Injection on serum homocysteine, high-sensitivity C-reactive protein and lipid levels in ischemic stroke

目的探讨丹参川芎嗪注射液对缺血性脑卒中患者血清中同型半胱氨酸、高敏C反应蛋白和血脂水平的影响以及临床疗效观察。方法选取2014年2月~2016年11月在广州中医药大学附属海南省中医院急诊科治疗的100例缺血性脑卒中患者,根据治疗方案分为观察组和对照组,每组各50例。对照组给予常规治疗,观察组加用丹参川芎嗪注射液。比较两组患者血清中同型半胱氨酸、高敏C反应蛋白和血脂水平,并评估两组患者的临床疗效和NIHSS评分。结果治疗后观察组患者血清中同型半胱氨酸、高敏C反应蛋白、总胆固醇、三酰甘油和脂蛋白a水平均明显低于对照组,差异有统计学意义(P<0.05)。观察组临床疗效和NIHSS评分均优于对照组,差异有统计学意义(P<0.05)。结论丹参川芎嗪注射液能降低缺血性脑卒中患者血清同型半胱氨酸、高敏C反应蛋白和血脂水平,提高临床疗效,优化患者神经功能改善。

Objective To explore the effect of Salvia Tetramethylpyrazine Injection on serum homocysteine, high-sensitivity C-reactive protein and lipid levels in ischemie stroke and clinical efficacy. Methods From February 2014 to November 2016, 100 patients with ischemic stroke in the emergency department of Chinese Medicine Hospital of Hainan Province, Guangzhou University of Chinese Medicine were selected and divided into treatment group and control group according to therapeutic schedule, with 50 cases in each group. The control group was treated with conventional treatment, while the treatment group was treated Salvia Tetramethylpyrazine Injection on the basis of control group. The serum homocysteine, high-sensitivity C-reactive protein, lipid levels, clinical efficacy, NIHSS score of the two groups were observed. Results After treatment, the levels of serum homocysteine, high-sensitivity C-reactive protein, total cholesterol, triaeylglycerol and lipoprotein （a） in the treatment group were lower than those in the control group, with statistically significant difference （ P 〈 0.05）. The NIHSS score and clinical efficacy of treatment group were significantly better than those of control group, with statistically significant difference （P 〈 0.05）. Conclusion Salvia Tetramethylpyrazine Injection can reduce the serum homoeysteine, high sensitivity c-reactive protein and serum lipid levels in patients with ischemie stroke, improve the clinical efficacy and neurological function.