氟苯尼考微囊的体外释放特性考察

Study on in-vitro release behavior of florfenicol microcapsules

为了考察氟苯尼考微囊在含5 m L/L吐温80的磷酸盐缓冲液（p H 6.8）中的释放特性,采用篮法进行氟苯尼考微囊的体外释放试验,并与游离的氟苯尼考原料药进行比较,进而对氟苯尼考微囊的释药模型进行拟合。结果显示,游离的氟苯尼考在15 min内基本释放完全;而自制氟苯尼考微囊1和微囊2中的药物可缓释至4 h,且自制氟苯尼考微囊2的药物释放稍缓慢于微囊1。模型拟合结果表明,自制氟苯尼考微囊1和微囊2的体外释药曲线分别与Ritger-Peppas方程和一级模型的拟合度较好。虽然两种自制的氟苯尼考微囊的药物释放机制有所区别,但是两种微囊均表现出一定的缓释作用,可为后续的临床试验研究和临床上药物的使用提供一定的参考价值。

The in vitro release behavior of florfenicol mierocapsules was investigated in phosphate buffer solution（pH6.8） containing 5mL/LTween 80 and compared with florfenicol bulk drug. The release mo- del of florfenicol microcapsules was also fitted. The results showed that florfenicol bulk drug was almost totally released at 15 min,but the drug release of the two self-prepared florfenicol micro- capsules could sustain to 4 h. The cumulative release rate of sample 2 was also found to be slower than that of sample l. And the release profile of self-prepared microcapsules of sample land 2 conformed to Ritger- Peppas equation and First-order equation,respectively. In conclusion,the two self-prepared florfenicol microcapsules exhibited sustained release effects with different release mechanisms,providing a refe- rence to future clinical studies and use of the self-prepared florfenicol microcapsules.