异甘草酸镁治疗肾综合征出血热肝损害患者的效果分析

Effect analysis of Magnesium Isoglycyrrhizinate on patients with hemorrhagic fever with renal syndrome

目的探讨对肾综合征出血热肝损害患者施行异甘草酸镁治疗的效果。方法选取2015年6月~2017年4月我院收治的60例肾综合征出血热肝损伤患者作为研究对象,根据随机分配法将其分为观察组和对照组,每组30例。对照组患者实施常规治疗,观察组患者在对照组治疗基础采用异甘草酸镁进行治疗。比较两组患者治疗过半时的的临床疗效、治疗前后血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平变化及平均治疗时间。结果在治疗过半时,观察组患者的治疗有效率(96.67%)显著高于对照组(73.33%),差异有统计学意义(P<0.05)。治疗前,两组患者的ALT、AST水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的ALT、AST水平显著低于对照组,平均治疗时间短于对照组,差异均有统计学意义(P<0.05)。结论对肾综合征出血热肝损害患者在普通治疗基础上,施行异甘草酸镁治疗,可以提高治疗的总有效率,有利于改善患者的肝脏功能,提高康复率,值得应用于临床推广。

Objective To investigate the effect of Magnesium Isoglycyrrhizinate on patients with hemorrhagic fever with renal syndrome.Methods A total of 60 patients with hemorrhagic fever with renal syndrome treated in our hospital from June 2015 to April 2017 were selected as subjects of this study.The patients were divided into observation group and control group by random assignment method,30 eases in each group.The control group was treated with routine treatment.The patients in the observation group were treated with Magnesium Isoglycyrrhizinate on the basis of the treatment of the control group.The clinical efficacy in the treatment of more than half, the change of alanine aminotransferase （ALT） aspartate amino acid transferase （AST） in the serum before and after treatment and the average treatment time of the two groups of patients were compared.Results In the treatment of more than half, the therapeutic efficiency of the observation group （96.67%） was significantly higher than that in the control group （73.33%）,and the difference was statistically significant （P〈0.05）.Before treatment,the levels of ALT and AST in the two groups were compared,and the differences were not statistically significant （P〉0.05）.After treatment,the levels of ALT and AST in the observation group was significantly lower than those in the control group,and the average treatment time was shorter than that in the control group,the differences were statistically significant （P〈0.05）.Conclusion The treatment of patients with hemorrhagic fever with renal syndrome is based on the general treatment.The treatment of Magnesium Isoglycyrrhizinate the total effective rate of the treatment,improve the liver function and improve the rehabilitation rate,and clinical application.