干扰素栓剂配合宫颈电热圈环切术治疗宫颈人乳头状瘤病毒感染的可行性

Interferon suppository with cervical electric loop possibility cutting treatment of cervical human papilloma virus infection

目的探讨干扰素栓剂配合宫颈电热圈环切术(LEEP)治疗宫颈人乳头状瘤病毒(HPV)感染的临床效果。方法选取我院2014年2月~2016年12月收治的100例有高危HPV感染的宫颈病变并实施LEEP手术患者,按照患者意愿分为对照组和研究组,每组各50例。对照组予以LEEP手术治疗,研究组予以干扰素栓剂配合LEEP治疗。比较两组患者临床效果、HPV转阴情况、中医证候评分、临床症状体征积分、创面愈合时间及不良反应发生情况。结果研究组临床治疗总有效率为94.00%,高于对照组的80.00%(P<0.05);研究组患者HPV转阴率为86.00%,高于对照组的64.00%,差异均有统计学意义(P<0.05)。干预前两组患者中医证候评分及临床症状体征积分比较,差异无统计学意义(P>0.05),干预后两组患者中医证候评分及临床症状体征积分均降低(P<0.05),且研究组低于对照组,差异有统计学意义(P<0.05)。研究组创面愈合时间短于对照组,差异有统计学意义(P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论干扰素栓剂配合LEEP治疗宫颈HPV感染可显著改善患者临床症状,疗效确切,具有一定安全性。

Objective To investigate the interferon suppository combined with loop electrosurgical excision procedure （LEEP） for the treatment of ceical human papilloma virus （HPV） infection in the clinical effect.Methods 100 cases of cervical infection with high-：risk HPV infection were treated in our hospital from February 2014 to December 2016,and LEEP operation was performed.The patients were divided into control group and study group according to the patients＇ wishes,50 cases in each group.The control group was treated with LEEP surgery,and the study group was treated with interferon suppository combined with LEEP treatment.The clinical efficacy,HPV negative condition,TCM syndrome score,clinical symptom and physical sign score,wound healing time and adverse reactions were compared between the two groups.Results The clinical effective rate of the study group （94.00%） was higher than that of the control group （80.00%） （P〈0.05）.The negative rate of HPV in the study group （86.00%） was higher than that in the control group （64.00%）（P〈 0.05）.Before the intervention,two groups of TCM syndrome score and clinical symptom score was not statistically significant （P〉0.05）,after the intervention of the two groups of TCM syndrome score and clinical symptom score were decreased （P〈0.05）,and the study group was lower than the control group （P〈0.05）.The wound healing time of the study group was shorter than that of the control group,the differences were statistically significant （P〈0.05）.There was no significant difference in the adverse reactions between the two groups （P〉0.05）.Conclusion Interferon suppository combined with LEEP in the treatment of cervical HPV infection can significantly improve the clinical symptoms of patients, the curative effect is exact,and has a certain security.