加味花生衣防治肿瘤化疗相关性血小板减少症的效果

Effect of modified peanut skin on prevention and treatment of tumor chemotherapy-related thrombocytopenia

目的观察加味花生衣防治化疗相关性血小板减少症的效果。方法选取我院2014年10月~2017年2月收治的132例出现化疗相关性血小板减少症的恶性肿瘤患者作为研究对象,随机分为治疗组(64例)和对照组(68例)。治疗组患者化疗的同时给予加味花生衣,对照组无任何预防措施。观察两组患者化疗后血小板(PLT)最低值、血小板<75×109/L及<100×109/L的持续时间、血小板减少的程度及不良反应。结果 2周期化疗后,治疗组患者的PLT最低值高于对照组,但差异无统计学意义(P>0.05);治疗组患者的血小板<75×109/L及<100×109/L的持续时间均明显短于对照组,差异有统计学意义(P<0.05);治疗组患者血小板下降的程度小于对照组,差异有统计学意义(P<0.05);未出现出血情况。结论预防性应用加味花生衣可减少化疗引起的血小板下降的幅度,缩短血小板低下的持续时间,值得临床推广。

Objective To observe the effect of modified peanut skin in the prevention and treatment of chemotherapyrelated thrombocytopenia.Methods From October 2014 to February 2017,132 patients with malignant tumor associated thrombocytopenia were enrolled as observation objects.They were randomly divided into treatment group （n=64） and control group （n=68）.In the treatment group,the modified peanut skin was provided besides chometherapy,while in the control group,no preventive measure was used.The minimum value of platelet,the duration of platelet less than 75×10^9/L and less than 100×10^9/L,the degree of thrombocytopenia,and adverse reactions after chemotherapy were observed in two groups.Results After two-cycle chemotherapy,the minimal PLT in the treatment group was higher than that in the control group,but without significant difference （P〉0.05）.The duration of platelet less than 75×10^9/L and less than 100×10^9/L in treatment group were significantly shorter than that in control group,the difference was significant difference （P〈 0.05）.In the treatment group,the decrease degree of thrombocytopenia was lower than that in the control group with a statistical difference （P〈0.05）.No bleeding was recun＇ed.Conclusion Preventive application of modified peanut skin can reduce the amplitude of platelet induced by chemotherapy and shorten the＇ duration of thrombocytopenia,which is worthy of clinical promotion.