丁丙诺啡透皮贴对痔术后镇痛效果的临床研究

The clinical study on the analgesic effect of buprenorphine transdermal patch after hemorrhoidectomy

目的评价丁丙诺啡透皮贴对痔术后镇痛的临床疗效。方法将60例行混合痔外剥内扎术患者,随机分为治疗组和对照组,每组各30例。对照组行术后常规治疗,治疗组在常规治疗的基础上加用丁丙诺啡透皮贴。VAS视觉模拟评分比较两组术后镇痛效果及相关不良反应发生情况。结果两组术后10 h VAS评分差异无统计学意义(Z=-1.240;P=0.215);术后1天(Z=-3.163;P=0.002),术后2天(Z=-2.793,P=0.005),3天(Z=-3.096,P=0.002)、4天(Z=-2.266,P=0.023)、5天(Z=-2.266,P=0.023)、6天(Z=-2.497,P=0.013)与对照组比较,对照组评分高于治疗组,差异均有统计学意义。两组于术后2天至5天疼痛评分逐渐升高后下降。结论丁丙诺啡透皮贴对痔术后患者镇痛效果良好,不良反应轻,值得临床推广。

ObjectiveTo evaluate the analgesic effect of buprenorphine transdermal patch after Milligan-Morgan hemorrhoidectomy. MethodsSixty patients under Milligan-Morgan hemorrhoidectomy were randomly divided into 2 groups, each group has 30 cases. The control group received routine postoperative treatment, while the treatment group was treated with buprenorphine transdermal patch on the basis of routine treatment. Compared the analgesic effect and adverse reactions between the two groups. ResultsThere was no signi？cant difference in VAS score between the two groups after operation in 10 h （Z=-1.240; P=0.215）. The difference was statistically signi？cant between the two groups after 1 （Z=-3.163; P=0.002）, 2 （Z=-2.793, P=0.005）, 3 （Z=-3.096, P=0.002）、4 （Z=-2.266, P=0.023）、5 （Z=-2.266, P=0.023）、 6 （Z=-2.497, P=0.013） days. From two to ？ve days after surgery, the pain of the two groups gradually increased, and then decreased. ConclusionThe buprenorphine transdermal patches have a good effect on postoperative analgesia of hemorrhoidectomy, and the adverse reactions are mild, so it is worthy of clinic application.