PEA3及β-catenin在卵巢上皮性癌组织中的表达及临床意义

Expression and clinical significance of PEA3 and beta-catenin in epithelial ovarian cancer

目的:探讨多瘤促活化因子(Polymoma virus enhancer 3,PEA3)及β-链蛋白(β-catenin)在卵巢上皮性癌组织中的表达及其影响因素。方法:回顾性分析120例卵巢上皮性癌患者的临床资料,同时选取具有正常卵巢组织的子宫肌瘤患者40例,卵巢良性肿瘤患者40例,卵巢交界性肿瘤患者40例;采用免疫组化SP法检测所有患者的PEA3及β-catenin水平;比较不同病理类型组织中的PEA3及β-catenin表达情况,影响因素及二者的相关性。结果:卵巢上皮性癌组织中PEA3、β-catenin表达阳性率均明显高于子宫肌瘤、卵巢良性肿瘤及卵巢交界性肿瘤,差异有统计学意义(P<0.05);卵巢上皮性癌组织中PEA3、β-catenin表达阳性率均与生存时间、术前CA125水平、组织学分级及腹腔转移有关,且PEA3与β-catenin表达水平呈正相关。结论:PEA3、β-catenin在卵巢上皮性癌组织中的表达呈特异性升高,可作为临床卵巢上皮性癌诊断的重要依据。

Objective： To investigate expression of polymoma virus enhancer 3 （PEA3） and beta-catenin in ovarian epithelialcancer and their influencing factors. Methods： The clinical data of 120 cases with ovarian epithelial cancer were retrospectively analyzed, including 40 cases of hysteromyoma, 40 cases of ovarian benign tumors, and 40 cases of borderline ovarian tumors. The PEA3and beta-catenin levels were detected by immunohistochemical SP method, and their expressions and influencing factors were compared. Further, the correlation between them was analyzed. Results： The positive expression rate of PEA3 in the ovarian epithelialcancer patients was significantly higher than those in the patients with hysteromyoma, ovarian benign tumors and borderline ovariantumors, and the differences were statistically significant （P〈0. 05）. The positive expression rate of PEA3 in the ovarian epithelialcancer patients was correlated with the survival time, preoperative CA125 level, histological grade and abdominal cavity metastasis.Further, the expression of PEA3 was positively correlated with that of beta-catenin. Conclusions： PEA3 and beta-catenin are highlyexpressed in epithelial ovarian cancer. Both of them are important references for the diagnosis of epithelial ovarian cancer.