大连地区体检人群高尿酸血症发病率调查及危险因素分析

Hyperuricemia incidence investigation and related risk factors in physical examination population of Dalian

目的:了解并分析大连地区体检人群高尿酸血症(Hyperuricemia,HUA)发病率及其影响因素。方法:回顾性分析42 572例体检者的临床资料,比较不同性别、年龄人群的尿酸(UA)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平及HUA检出率,并分析HUA的独立危险因素。结果:71~97岁人群的尿酸水平明显高于其他年龄段人群(P<0.05);男性血清尿酸水平随年龄增长逐渐下降;女性血清尿酸水平随年龄增长逐渐升高;体检人群中男性HUA检出率明显高于女性(P<0.05);高TG、高TC、高LDL-C和男性均是HUA的独立危险因素。结论:大连地区HUA发病率为26.34%,HUA的危险因素包括高TG、高TC、高LDL-C、男性,HUA的保护因素是高HDL-C和高FBG。

Objective： To investigate and analyze hyperuricemia （HUA） incidence rate and related risk factors in physical examination population of Dalian. Methods： The clinical data of 42572physical examination population were retrospectively analyzed.The levels of uric acid （UA）, fasting blood glucose （FBG）, total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）, and the HUA detection rates among different sex and age groupwere compared, and the independent risk factors of HUA were analyzed. Results： The UA levels in the 71-97 years group were significantly higher than those of other years group （P〈0. 05）. The serum UA levels in the male people decreased with the increase of age,while those of the female people increased withthe increase of age. Among the physical examination population, the male HUA detection rate was significantly higher than that of the female （P〈0. 05）. Moreover, high TG, TC and LDL-C as well as male were the independent risk factors of HUA. Conclusions： The HUA incidence rate of HUA in Dalian is 26. 34%. The risk factors of HUA are highTG, TC and LDL-C as well as male, while the protective factors were high HDL-C and FBG.