乳头状汗腺腺瘤10例临床病理分析

Hidradenoma Papilliferum: A Clinicopathologic Analysis of 10 Cases

目的探讨乳头状汗腺腺瘤的临床病理学特点、免疫组化、诊断与鉴别诊断。方法收集乳头状汗腺腺瘤10例,观察病理学形态及免疫组化表型,通过随访了解预后。结果患者均为女性,平均42岁。肿物直径0.5~1.7 cm。镜下观察肿瘤由囊状、腺管状和乳头状结构所构成,上皮由内层柱状上皮和外层肌上皮所构成。免疫组化:标记3例的肿瘤内层柱状上皮CKPan、CAM5.2(+),2例EMA(+),1例ER、PR(+);所有外层肌上皮细胞SMA、P63、S-100(+)。结论乳头状汗腺腺瘤是一种少见的皮肤良性肿瘤,确诊主要依赖病理学检查,肿瘤完整切除后不复发。

Objective In order to study the clinicopathologic characteristics, immunohistochemisrty, diagnosis and differential diagnosis of hidradenoma papilliferum. Methods Ten cases of hidradenoma papilliferum were collected to investigate the clinicopathological features, immunohistochemical expression and to evaluate the prognosis by follow-up.Results All of the patients were females, with an average age of 42 years. The tumors were 0.5 cm to 1.7 cm in diameter.Microscopic examination showed that the tumor consisted of cystic, glandular and papillary structures. Those structures consisted of inner columnar epithelial cells and outer myoepithelial cells. Immunohistochemistry showed that the epithelial cells of three cases were positive for CKPan and CAM5.2, two cases expressed EMA, one case expressed ER and PR. The myoepithelial cells of three cases were positive for SMA, P63 and S-100. Conclusion Hidradenoma papilliferum is a rare benign tumor of the skin. Diagnosis is based on histopathology. No recurrence is observed after a complete excision.