早期糖尿病肾病与血细胞形态变化的关系

Relationship between early diabetic nephropathy and morphological changes of blood cells

目的:探讨早期糖尿病肾病与血细胞形态变化的关系。方法:选择糖尿病肾病患者90例作为研究组,选择健康体检者86例作为参照组,均测定血糖、血压、尿白蛋白排泄率、血细胞形态、血生化指标及肾小球形态变化。结果:研究组患者血压、血糖、尿白蛋白排泄率及血红细胞压积等显著高于参照组,而MCHC低于参照组(P<0.05);肾小球增生、体积等评分与参照组比较,差异有统计学意义(P<0.05)。结论:早期DN患者与血细胞形态、血压、尿白蛋白排泄率等相关指数改变有关,且相互之间具有关联性。

Objective:To explore the relationship between early diabetic nephropathy and morphological changes of blood cells.Methods:90 patients with diabetic nephropathy were selected as the study group,and 86 healthy subjects were selected as the reference group.Blood glucose,blood pressure,urinary albumin excretion rate,blood cell morphology and blood biochemical parameters and morphological changes of glomeruli were detected.Results:In the study group,BP,GLU,UAER and PVC were significantly higher than those of the reference group,while the MCHC index was lower than that of the reference group(P<0.05).Glomerular proliferation,volume and other scores were statistically significant compared with the reference group(P<0.05).Conclusion:Early DN patients were associated with changes in blood cell morphology,blood pressure,albumin excretion rate and other related indexes,and they were related to each other.