FEV3/FVC下降与早期气流受限的关系

Relationship between FEV_3/FVC reduction and early airway obstruction in pulmonary function testing

目的探讨FEV_3/FVC与肺通气功能之间的关系及其在肺功能检查中的临床意义。方法根据常规肺功能检测(pulmonary function test,PFT)结果将受试的242例患者分为正常FEV_3/FVC和FEV_1/FVC组(A组,n=62)、仅FEV_3/FVC下降组(B组,n=40)及FEV_1/FVC下降组(C组,n=140)。观察三组受试者的肺功能指数变化。结果 A组的年龄低于B组(P<0.05)和C组(P<0.01)。A组的BMI高于C组(P<0.01)。肺功能检测中,A组FVC%pred及MEF_(50%p)red高于B组(P<0.05)。A组的FEV_1%pred、FEV_1/FVC、FEV_3/FVC、FEF_(25%~75%)、FEF_(25%~75%)pred、MEF25%及MEF_(25%)pred均高于B组(P均<0.01)。而PFT的其他指标如FVC、FEV_1、FEV_3、MEF_(75%)、MEF_(75%)pred及MEF_(50%)与B组比较均无统计学差异。肺功能检测中A组的各项指标均高于C组(P均<0.01)。肺功能检测中B组的各项指标均高于C组(P均<0.01)。结论 FEV_3/FVC单独下降可能提示早期的气道阻塞,FEV_3/FVC可能是判断早期气道阻塞更敏感的指标。

Objective To investigate the relationship between FEV_3/FVC in pulmonary function tests and the lung ventilation function.Methods Two hundred and forty two subjects underwent pulmonary function tests(PFT),the normal FEV_3/FVC and FEV_1/FVC was detected in 62 cases(group A),abnormal FEV_3/FVC in 40 cases(group B) and abnormal FEV_1/FVC in 140 cases(group C).Results The age of group A was lower than that of group B(P < 0.05) and group C(P < 0.01).BMI of group A was higher than that of group C(P < 0.01).In PFT,FVC% pred and MEF_(50%)pred of group A were higher than those of group B(P < 0.05).FEV_1% pred,FEV_1/FVC,FEV_3/FVC,FEF_(25% ~ 75%),FEF_(25% ~ 75%)pred,MEF_(25%)and MEF_(25%)pred of group A were higher than those of group B(P < 0.01).While other indicators in PFT,including FVC,FEV_1,FEV_3,MEF_(75%),MEF_(75%)pred and MEF_(50%)in group A had no statistically differents with group B.In PFT,the indicators of group A were higher than those of group C(P < 0.01),and the indicators of group B were higher than those of group C(P < 0.01).Conclusion The subjects of airway obstruction present with a reduced FEV_3/FVC,which may be a more sensitive indicator for early airway obstruction.