男性不育患者生殖激素水平与精子质量的相关分析

Correlation between reproductive hormone levels and sperm quality in male infertility patients

目的研究并探讨男性不育患者生殖激素水平与其精子质量的相关性。方法收集2013年1月至2017年5月期间,在我院就诊的男性不育患者200例,所有患者进行生殖激素水平测定和精液分析,根据其精液分析结果中的精子形态学情况,分为A组(精子形态正常率<4%)、B组(精子形态正常率≥4%且<10%)、C组(精子形态正常率≥10%),比较不同精子形态学患者的卵泡刺激素(FSH)、黄体生成素(LH)及睾酮(T)激素水平;再根据生殖激素水平检测结果将患者分为生殖激素水平正常组和生殖激素水平异常组,比较不同生殖激素水平患者的精子密度、精子活动力、精子存活率、精子形态正常率等指标,并对精子质量与其生殖激素水平进行相关性分析。结果 A、B、C三组患者之间的FSH、LH、T水平均呈显著上升趋势(P<0.05);生殖激素水平异常组患者的精子密度[(13.21±7.09)#106/ml vs.(24.95±10.72)#106/ml]、精子活动力[(35.83±11.17)%vs.(53.74±15.86)%]、精子存活率[(48.79±8.95)%vs.(59.64±10.21)%]、精子形态正常率[(6.13±1.85)%vs.(10.56±4.29)%]均低于激素水平正常组,差异有统计学意义(P<0.05);皮尔逊相关系数分析显示,精子密度、精子活动力、精子存活率、精子形态等精子质量指标均与患者生殖激素水平显著相关(P<0.05)。结论男性不育患者的精子密度、精子活动力、精子存活率、精子形态等精子质量指标与其生殖激素水平显著相关,生殖激素水平检测联合精液分析,可为男性不育的临床诊治提供指导性意见。

Objective： To investigate the correlation between reproductive hormone levels and sperm quality in male infertility patients. Methods： The data of reproductive hormone levels and semen analysis in 200 male infertility patients in our hospital from January 2013 to May 2017 were analyzed. According to the sperm normal morphology percentage,the patients were divided into group A （〈4%）,group B （≥4% and〈10%） and group C （≥10%）. The FSH,LH and testosterone （T） levels were compared among the three groups. According to the reproductive hormone levels, the patients were divided into normal group and abnormal group. The sperm density, sperm motility, sperm survival rate and sperm morphology normal rate were compared among the groups, and the correlation between reproductive hormone levels and sperm quality was analyzed. Results： The FSH,LH,T levels in A,B and C group showed a significant upward trend （P〈0.05）. The sperm density [（ 13.21 ± 7.09） vs. （24.95 ± 10.72） 10^6/ml], sperm motility[（ 35.83± 11.17 ） % vs. （ 53.74 ± 15.86） %1, sperm survival rate [（48. 79±8. 95）% vs. （59.64± 10. 21）], sperm normal morphology rate [-（6.13± 1.85） ] vs. （10.56±4.29）] were significantly lower in abnormal reproductive hormone level group than those in normal reproductive hormone level group （P 〈0.05）. Pearson correlation coefficient analysis showed that the sperm density, sperm motility, sperm survival rate and sperm normal morphology rate were significantly correlated with serum reproductive hormone levels （P〈0.05）. Conclusions： The sperm density, sperm motility, sperm survival rate and sperm normal morphology rate are significantly related to reproductive hormone levels. Detection of reproductive hormone combined with semen analysis can provide guidance for clinical diagnosis and treatment of male infertility.