环境响应型智能探针应用于肿瘤治疗的研究进展

Advances in application of environment-responsive smart probes in tumor therapy

随着纳米医学研究的不断深入,科学家们发现,纳米药物传递系统可以促进抗肿瘤药物在肿瘤内的聚集,降低药物对周围正常组织的杀伤作用,从而增加治疗效果并减少不良反应。近年来,纳米药物传递系统逐步向智能化发展,并且人们已设计出大量对肿瘤微环境敏感的刺激响应型智能探针。这类探针可分为内环境(包括p H、酶和还原环境)响应型和外环境(包括光、温度、超声和磁场)响应型两大类。本文即对这两类环境刺激响应型探针在抗肿瘤领域的研究进展进行综述,并展望其未来的研究方向。

With the development of medical nanotechnology, scientists have found that nanoparticle drug delivery system can improve the accumulation of anti-tumor drugs inside the tumor and reduce the damage to normal tissues, so as to increase the treatment effect while decrease its side effect. In recent years, the nanoparticle drug delivery system has been gradually developing towards intellectualization, and various smart probes which are stimuli- responsive and sensitive to microenvironment of tumor have been designed. Those probes can be divided into two categories： internal （including pH, enzyme, and redox） and external （including light, temperature, ultrasound, and magnetic field） environment-responsive probes. In this paper, the latest research progress in the two kinds of environment-responsive smart probes in the field of tumor therapy is reviewed, and the further research direction is also prospected.