经支气管内镜治疗气管-支气管结核76例的疗效

Efficacy of interventional bronchoscopy in treatment of 76 patients with tracheobronchial tuberculosis

目的本研究旨在探讨支气管镜介入治疗对支气管内膜结核的治疗价值。方法回顾性分析经支气管镜检查并病理确诊76例初治支气管结核患者的临床病理资料,根据治疗方式不同分为常规治疗组(20例)和支气管内镜联合治疗组(56例),对比分析两组患者一般特征及治疗效果。结果联合治疗组在症状缓解时间、痰菌阴转时间、阴转率及总体疗效等方面均显著优于常规治疗组(P<0.05)。观察期内两组患者均未出现治疗有关严重不良反应。相关分析发现治疗次数与病变侵犯面积(r=0.296,P=0.025<0.05)以及病理类型(r=0.323,P=0.014<0.05)呈正相关。结论支气管镜下介入治疗是治疗气管-支气管结核的有效手段,应提倡早期积极干预。

Objective This study investigated the use of interventional bronchoscopic techniques in man- agement of patients with tracheobronchial tuberculosis. Methods In this retrospective study, we analyzed the clinical data of 76 patients with endobronchial tuberculosis. All patients underwent bronchoscopy examination and diag- nosed by pathology. According to different treatments, the patients were divided into two groups, the observation group （56 cases ） adopted by bronchoscopy and chemotherapy and the control group （20 eases ） adopted by chemo- therapy only. The general features, treatment effectiveness in the two groups were compared and analyzed. Results Compared with the control group, the sputum negative rate, the recovery rate of symptom, and the total effective rate were higher （P 〈 0.05 ）. No severe side effects were found in the two groups. There was a positive rela- tionship among frequency of bronchoseopy, the area of lesion （r = 0.296, P = 0.025 〈 0.05） and the type of histology （r = 0.323, P = 0.014 〈 0.05）. Conclusions It is concluded that interventional bronchoscopic techniques are useful in management of patients with endobronehial tuberculosis.